UniProt Accession

 VPS29_MOUSE; Q9QZ88; Q3UCZ0; Q9D107 

Genbank Protein ID

 AF193794; AK004103; AK150330; BC005663 

Genbank Nucleotide ID

 AAF04595.1; BAB23170.1; BAE29472.1; AAH05663.1 

Protein Name

 Vacuolar protein sorting-associated protein 29 

Protein Synonyms/Alias

 Vesicle protein sorting 29 

Gene Name

 Vps29 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	KESYDYLKTLAGDVH	ubiquitination	[1]
73	NLNYPEQKVVTVGQF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p- nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro). 

Sequence Annotation

 METAL 8 8 Zinc 1.
 METAL 10 10 Zinc 1.
 METAL 39 39 Zinc 1.
 METAL 39 39 Zinc 2.
 METAL 62 62 Zinc 2.
 METAL 86 86 Zinc 2.
 METAL 115 115 Zinc 2.
 METAL 117 117 Zinc 1.
 MOD_RES 50 50 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
 GO:0006896; P:Golgi to vacuole transport; ISS:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR024654; Calcineurin-like_PEstase_dom.
 IPR000979; Phosphodiesterase_MJ0936. 

Pfam

 PF12850; Metallophos_2 

SMART

  

PROSITE

  

PRINTS