UniProt Accession

 BL1S1_MOUSE; O55102; Q9DC96 

Genbank Protein ID

 Y13778; Y13779; Y13780; Y13781; AK003035; BC034662 

Genbank Nucleotide ID

 CAA74108.1; CAA74108.1; CAA74108.1; CAA74108.1; BAB22523.1; AAH34662.1 

Protein Name

 Biogenesis of lysosome-related organelles complex 1 subunit 1 

Protein Synonyms/Alias

 BLOC-1 subunit 1; GCN5-like protein 1 

Gene Name

 Bloc1s1 

Gene Synonyms/Alias

 Gcn5l1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	TALEYVYKGQLQSAP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5A1 and NDUFA9. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 125 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; IDA:MGI.
 GO:0005758; C:mitochondrial intermembrane space; IDA:UniProtKB.
 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0009060; P:aerobic respiration; ISS:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB.
 GO:0031175; P:neuron projection development; NAS:UniProtKB.
 GO:0018394; P:peptidyl-lysine acetylation; ISS:UniProtKB. 

Interpro

 IPR009395; GCN5L1. 

Pfam

 PF06320; GCN5L1 

SMART

  

PROSITE

  

PRINTS