CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042031
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sphingomyelin phosphodiesterase 4 
Protein Synonyms/Alias
  
Gene Name
 SMPD4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
164LHHTSLLKRHISHQTubiquitination[1, 2, 3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 724 AA 
Protein Sequence
MAGRKHFWQP RWCPRWLEPP LLTGARESCG VQHRDGISRP WGPVKASIQE CILPDSPLYH 60
NKVQFTPTGG LGLNLALNPF EYYIFFFALS LITQKPLPVS LHVRTSDCAY FILVDRYLSW 120
FLPTEGSVPP PLSSSPGGTS PSPPPRTPAI PFASYGLHHT SLLKRHISHQ TSVNADPASH 180
EIWRSETLLQ VFVEMWLHHY SLEMYQKMQS PHAKESFTPT EEHVLVVRLL LKHLHAFANS 240
LKPEQASPSA HSHATSPLEE FKRAAVPRFV QQKLYLFLQH CFGHWPLDAS FRAVLEMWLS 300
YLQPWRYAPD KQAPGSDSQP RCVSEKWAPF VQENLLMYTK LFVGFLNRAL RTDLVSPKHA 360
LMVFRVAKVF AQPNLAEMIQ KGEQLFLEPE LVIPHRQHRL FTAPTFTGSF LSPWPPAVTD 420
ASFKVKSHVY SLEGQDCKYT PMFGPEARTL VLRLAQLITQ AKHTAKSISD QCAESPAGHS 480
FLSWLGFSSM DTNGSYTAND LDEMGQDSVR KTDEYLEKAL EYLRQIFRLS EAQLRQFTLA 540
LGTTQDENGK KQLPDCIVGE DGLILTPLGR YQIINGLRRF EIEYQGDPEL QPIRSYEIAS 600
LVRTLFRLSS AINHRFAGQM AALCSRDDFL GSFCRYHLTE PGLASRHLLS PVGRRQVAGH 660
TRGPRLSLRF LGSYRTLVSL LLAFFVASLF CVGPLPCTLL LTLGYVLYAS AMTLLTERGK 720
LHQP 724 
Gene Ontology
 GO:0050290; F:sphingomyelin phosphodiesterase D activity; IEA:InterPro. 
Interpro
 IPR024129; Sphingomy_SMPD4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS