| Tag | Content |
|---|
| CPLM ID | CPLM-016396 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PAB-dependent poly(A)-specific ribonuclease subunit 2 |
Protein Synonyms/Alias | Inactive ubiquitin carboxyl-terminal hydrolase 52 |
Gene Name | Pan2 |
Gene Synonyms/Alias | Kiaa0710; Usp52 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 499 | KVTIKYSKLGLEDFD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions in cytoplasmic mRNA decay. As part of the Pan nuclease complex, shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein (By similarity). |
Sequence Annotation | DOMAIN 973 1146 Exonuclease.
MOD_RES 784 784 Phosphoserine (By similarity).
MOD_RES 1188 1188 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Exonuclease; Hydrolase; Nonsense-mediated mRNA decay; Nuclease; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1200 AA |
Protein Sequence | MNFEGLDPGL AEFSPAMHST LDPVLDAHLN PSLLQNVELD PEGVALEALP VQESVHIMEG 60
VYSELHSVVA EVGVPVSVSH FDLHEEMLWV GSHGGHATSF FGPALERYSS FQVNGGDDIR 120
QIQSLENGIL FLTKNNLKYM ARGGLIIFDY LLDENEDMHS VLLTDNSTLL VGGLQNHVLE 180
IDLNTVQETQ KYAVETPGVT IMRQTNRFFF CGHTSGKVSL RDLRSFKVEH EFDAFSGSLS 240
DFDVHGNLLA ACGFSSRLTG LACDRFLKVY DLRMMRAITP LQVHVDPAFL RFIPTYTSRL 300
AIISQSGQCQ FCEPTGLANP ADIFHVNPVG PLLMTFDVSA SKQALAFGDS EGCVHLWTDS 360
PEPSFNPYSR ETEFALPCLV DSLPPLDWSQ DLLPLSLIPV PLTTDALLSD WPAANSAPAP 420
RRAPPVDAEI LRTMKKVGFI GYAPNPRTRL RNQIPYRLKE SDHEFDNFSQ VTESPTGREE 480
EPLHTVSKKY RKVTIKYSKL GLEDFDFKHY NKTLFAGLEP HIPNAYCNCM IQVLYFLEPV 540
RCLIQNHLCQ KEFCLACELG FLFHMLDLSR GDPCQGSNFL RAFRTIPEAS ALGLILADSD 600
EASGKGSLAR LIQRWNRFIL TQLHQDMQEL EVPQAYRGAG GSFCSSGDSI IGQLFSCEME 660
NCSLCRCGSE TVRASSTLLF TLSYPEDKTG KNYDFAQVLK RSICLEQNTQ AWCDNCEKYQ 720
PTIQTRNIRH LPDILVINCE VNSSKEADFW RLQAEVAFKI AVKKYGGEMK SKEFALADRK 780
ELRSPEGFLC SSIEELKNVW LPFSIRMKMT KNKGLDVCNW ADEHELSSLG APSQWGPARA 840
EEELGVYVYD LMATVVHILD SRTGGSLVAH IKVGETYHQR KEGVTHQQWY LFNDFLIEPI 900
DKYEAVQFDM NWKVPAILYY VKRNLNSRYN LNIKNPIEAS VLLAEASLAR KQRKTHTTFI 960
PLMLNEMPQV GDLVGLDAEF VTLNEEEAEL RSDGTKSTIK PSQMSVARIT CVRGQGPNEG 1020
IPFIDDYIST QEQVVDYLTQ YSGIKPGDLD AKISSKHLTT LKSTYLKLRF LIDIGVKFVG 1080
HGLQKDFRVI NLMVPKDQVL DTVYLFHMPR KRMISLRFLA WYFLDLKIQG ETHDSIEDAR 1140
TALQLYRKYL ELSKNGTEPE SFHKVLKGLY EKGRKMDWKV PEPESQTSPK NAAVFSVLAL 1200 |
Gene Ontology | GO:0000932; C:cytoplasmic mRNA processing body; IDA:MGI. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0031251; C:PAN complex; ISS:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0004535; F:poly(A)-specific ribonuclease activity; ISS:UniProtKB. GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |