| Tag | Content |
|---|
| CPLM ID | CPLM-000610 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calpain-6 |
Protein Synonyms/Alias | |
Gene Name | Capn6 |
Gene Synonyms/Alias | Capa6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | FNRLLPGKVVWKRPQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues. |
Sequence Annotation | DOMAIN 26 343 Calpain catalytic.
DOMAIN 518 620 C2.
REGION 344 495 Domain III. |
Keyword | Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 641 AA |
Protein Sequence | MGPPLKLFKN QKYQELKQEC MKDGRLFCDP TFLPENDSLF FNRLLPGKVV WKRPQDISDD 60
PHLIVGNISN HQLIQGRLGN KAMISAFSCL AVQESHWTKA IPNHKDQEWD PRKPEKYAGI 120
FHFRFWHFGE WTEVVIDDLL PTINGDLVFS FSTSMNEFWN ALLEKAYAKL LGCYEALDGL 180
TITDIIMDFT GTLAEIIDMQ KGRYTDLVEE KYKLFGELYK TFTKGGLICC SIESPSQEEQ 240
EVETDWGLLK GYTYTMTDIR KLRLGERLVE VFSTEKLYMV RLRNPLGRQE WSGPWSEISE 300
EWQQLTVTDR KNLGLVMSDD GEFWMSLEDF CHNFHKLNVC RNVNNPVFGR KELESVVGCW 360
TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM SLQQKDLRTY RRMGRPDNYI 420
IGFELFKVEM NRRFRLHHLY IQERAGTSTY IDTRTVFLSK YLKKGSYVLV PTMFQHGRTS 480
EFLLRIFSEV PVQLRELTLD MPKMSCWNLA RGYPKVVTQI TVHSAEGLEK KYANETVNPY 540
LIIKCGKEEV RSPVQKNTVH AIFDTQAIFY RRTTDIPIII QVWNSRKFCD QFLGQVTLDA 600
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L 641 |
Gene Ontology | GO:0005874; C:microtubule; IDA:UniProtKB. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0005876; C:spindle microtubule; IEA:Compara. GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro. GO:0008017; F:microtubule binding; IDA:UniProtKB. GO:0001578; P:microtubule bundle formation; IMP:UniProtKB. GO:0006508; P:proteolysis; IEA:InterPro. GO:0051493; P:regulation of cytoskeleton organization; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |