UniProt Accession

 RN187_MOUSE; Q8BFX1; Q4VA64; Q8C2B0; Q8CAS0; Q9JMF6 

Genbank Protein ID

 AB030190; AK037991; AK075944; AK076158; AK088973; AL662809; BC072613; BC096522 

Genbank Nucleotide ID

 BAA92754.1; BAC29916.1; BAC36073.1; BAC36225.1; BAC40679.1; CAM24481.1; AAH72613.1; AAH96522.1 

Protein Name

 E3 ubiquitin-protein ligase RNF187 

Protein Synonyms/Alias

 RING domain AP1 coactivator 1; RACO-1; RING finger protein 187 

Gene Name

 Rnf187 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
141	GSVEIMRKDLNDARD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8 (By similarity). 

Sequence Annotation

 ZN_FING 12 53 RING-type.
 CROSSLNK 195 195 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 224 224 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 225 225 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Cytoplasm; Isopeptide bond; Ligase; Metal-binding; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 236 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.
 GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. 

Interpro

 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 

Pfam

 PF00097; zf-C3HC4 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS