UniProt Accession

 NTAN1_HUMAN; Q96AB6 

Genbank Protein ID

 BC017336 

Genbank Nucleotide ID

 AAH17336.1 

Protein Name

 Protein N-terminal asparagine amidohydrolase 

Protein Synonyms/Alias

 Protein NH2-terminal asparagine amidohydrolase; PNAA; Protein NH2-terminal asparagine deamidase; PNAD; Protein N-terminal Asn amidase; Protein NTN-amidase 

Gene Name

 NTAN1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
295	GNKALLYKKNEDGLW	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 310 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008418; F:protein-N-terminal asparagine amidohydrolase activity; IEA:Compara.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara. 

Interpro

 IPR026750; NTAN1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS