CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 4-hydroxyphenylpyruvate dioxygenase 
Protein Synonyms/Alias
 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein 
Gene Name
 Hpd 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
127EPWVEEDKFGKVKFAacetylation[1]
130VEEDKFGKVKFAVLQacetylation[1]
132EDKFGKVKFAVLQTYacetylation[1]
149TTHTLVEKINYTGRFacetylation[1]
166GFEAPTYKDTLLPKLacetylation[1]
311KTSKIQVKENMDVLEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Key enzyme in the degradation of tyrosine. 
Sequence Annotation
 METAL 183 183 Iron.
 METAL 266 266 Iron.
 METAL 349 349 Iron.
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 250 250 Phosphoserine (By similarity).  
Keyword
 3D-structure; Acetylation; Complete proteome; Cytoplasm; Dioxygenase; Endoplasmic reticulum; Golgi apparatus; Iron; Membrane; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Phosphoprotein; Reference proteome; Tyrosine catabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MTTYSNKGPK PERGRFLHFH SVTFWVGNAK QAASFYCNKM GFEPLAYKGL ETGSREVVSH 60
VIKQGKIVFV LCSALNPWNK EMGDHLVKHG DGVKDIAFEV EDCEHIVQKA RERGAKIVRE 120
PWVEEDKFGK VKFAVLQTYG DTTHTLVEKI NYTGRFLPGF EAPTYKDTLL PKLPSCNLEI 180
IDHIVGNQPD QEMESASEWY LKNLQFHRFW SVDDTQVHTE YSSLRSIVVA NYEESIKMPI 240
NEPAPGRKKS QIQEYVDYNG GAGVQHIALR TEDIITTIRH LRERGMEFLA VPSSYYRLLR 300
ENLKTSKIQV KENMDVLEEL KILVDYDEKG YLLQIFTKPM QDRPTLFLEV IQRHNHQGFG 360
AGNFNSLFKA FEEEQALRGN LTDLETNGVR SGM 393 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.
 GO:0000139; C:Golgi membrane; IDA:RGD.
 GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0006572; P:tyrosine catabolic process; IDA:UniProtKB. 
Interpro
 IPR005956; 4OHPhenylPyrv_dOase.
 IPR004360; Glyas_Fos-R_dOase_dom. 
Pfam
 PF00903; Glyoxalase 
SMART
  
PROSITE
  
PRINTS