UniProt Accession

 A0M8W4_HUMAN; A0M8W4 

Genbank Protein ID

 DQ003720; AK313447; CH471068 

Genbank Nucleotide ID

 AAY16979.1; BAG36236.1; EAW86688.1 

Protein Name

 Ubiquitin-conjugating enzyme E2 variant 2 

Protein Synonyms/Alias

 Ubiquitin-conjugating enzyme E2 variant 2, isoform CRA_b; cDNA, FLJ93989, Homo sapiens ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2),mRNA 

Gene Name

 UBE2V2 

Gene Synonyms/Alias

 hCG_1640505 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MAVSTGVKVPRNFRL	ubiquitination	[1]
66	ENRIYSLKVECGPKY	ubiquitination	[2]
72	LKVECGPKYPEAPPS	ubiquitination	[1, 2]
108	RSIPVLAKWQNSYSI	ubiquitination	[1, 2]
129	LRRLMMSKENMKLPQ	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

  

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0045739; P:positive regulation of DNA repair; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0051965; P:positive regulation of synapse assembly; IEA:Compara. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS