UniProt Accession

 SOSB1_HUMAN; Q9BQ15; A6NDF8; Q6XYC8 

Genbank Protein ID

 AY203942; CH471054; AC073896; BC001079; BC006171 

Genbank Nucleotide ID

 AAP34465.1; EAW96913.1; AAH01079.1; AAH06171.1 

Protein Name

 SOSS complex subunit B1 

Protein Synonyms/Alias

 Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1 

Gene Name

 NABP2 

Gene Synonyms/Alias

 OBFC2B; SSB1; LP3587 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MTTETFVKDIKPGLK	ubiquitination	[1]
11	ETFVKDIKPGLKNLN	ubiquitination	[1]
72	GDIIRLTKGYASVFK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. 

Sequence Annotation

 DNA_BIND 22 92 OB.
 MOD_RES 117 117 Phosphothreonine; by ATM.  

Keyword

 Alternative splicing; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0070876; C:SOSS complex; IDA:UniProtKB.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0000075; P:cell cycle checkpoint; IMP:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
 GO:0010212; P:response to ionizing radiation; IMP:UniProtKB. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR004365; NA-bd_OB_tRNA-helicase. 

Pfam

 PF01336; tRNA_anti 

SMART

  

PROSITE

  

PRINTS