CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG10343, isoform CRA_b 
Protein Synonyms/Alias
 Phosphate carrier protein, mitochondrial 
Gene Name
 Slc25a3 
Gene Synonyms/Alias
 mCG_10343 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
95RMQVDPQKYKGIFNGacetylation[1, 2, 3, 4]
95RMQVDPQKYKGIFNGubiquitination[5]
97QVDPQKYKGIFNGFSacetylation[4]
108NGFSITLKEDGVRGLacetylation[3]
133YSMQGLCKFGFYEVFacetylation[3]
202TLREAVPKMYKEEGLacetylation[4]
205EAVPKMYKEEGLNAFacetylation[1, 2, 3, 4, 6, 7, 8]
205EAVPKMYKEEGLNAFsuccinylation[8]
205EAVPKMYKEEGLNAFubiquitination[5]
214EGLNAFYKGVAPLWMacetylation[2, 4]
230QIPYTMMKFACFERTacetylation[3, 4]
230QIPYTMMKFACFERTubiquitination[5]
243RTVEALYKFVVPKPRacetylation[2]
291VSVLNKEKGSTASQVacetylation[4]
291VSVLNKEKGSTASQVubiquitination[5]
309LGFRGVWKGLFARIIacetylation[8]
309LGFRGVWKGLFARIIsuccinylation[8]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [6] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [8] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MFSSVAHLAR ANPFNAPHLQ LVHDGLSGPR SPPAPPRRSR HLAAAAVEEQ YSCEYGSGRF 60
FLLCGLGGII SCGTTHTALV PLDLIKCRMQ VDPQKYKGIF NGFSITLKED GVRGLAKGWA 120
PTLIGYSMQG LCKFGFYEVF KALYSNILGE ENTYLWRTSL YLASSASAEF FADIALAPME 180
AAKVRIQTQP GYANTLREAV PKMYKEEGLN AFYKGVAPLW MRQIPYTMMK FACFERTVEA 240
LYKFVVPKPR SECTKAEQLV VTFVAGYIAG VFCAIVSHPA DSVVSVLNKE KGSTASQVLQ 300
RLGFRGVWKG LFARIIMIGT LTALQWFIYD SVKVYFRLPR PPPPEMPESL KKKLGLTE 358 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS