| Tag | Content |
|---|
| CPLM ID | CPLM-001546 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kelch-like protein 2 |
Protein Synonyms/Alias | Actin-binding protein Mayven |
Gene Name | KLHL2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 333 | SVECYDFKEERWHQV | ubiquitination | [1] | | 515 | HDGPLVRKSVEVYDP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. |
Sequence Annotation | DOMAIN 56 123 BTB.
REPEAT 308 353 Kelch 1.
REPEAT 354 400 Kelch 2.
REPEAT 402 447 Kelch 3.
REPEAT 449 496 Kelch 4.
REPEAT 497 543 Kelch 5.
REPEAT 545 591 Kelch 6. |
Keyword | 3D-structure; Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Kelch repeat; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 593 AA |
Protein Sequence | MVWLEARPQI LFVCTKQGHQ KPLDSKDDNT EKHCPVTVNP WHMKKAFKVM NELRSQNLLC 60
DVTIVAEDME ISAHRVVLAA CSPYFHAMFT GEMSESRAKR VRIKEVDGWT LRMLIDYVYT 120
AEIQVTEENV QVLLPAAGLL QLQDVKKTCC EFLESQLHPV NCLGIRAFAD MHACTDLLNK 180
ANTYAEQHFA DVVLSEEFLN LGIEQVCSLI SSDKLTISSE EKVFEAVIAW VNHDKDVRQE 240
FMARLMEHVR LPLLPREYLV QRVEEEALVK NSSACKDYLI EAMKYHLLPT EQRILMKSVR 300
TRLRTPMNLP KLMVVVGGQA PKAIRSVECY DFKEERWHQV AELPSRRCRA GMVYMAGLVF 360
AVGGFNGSLR VRTVDSYDPV KDQWTSVANM RDRRSTLGAA VLNGLLYAVG GFDGSTGLSS 420
VEAYNIKSNE WFHVAPMNTR RSSVGVGVVG GLLYAVGGYD GASRQCLSTV ECYNATTNEW 480
TYIAEMSTRR SGAGVGVLNN LLYAVGGHDG PLVRKSVEVY DPTTNAWRQV ADMNMCRRNA 540
GVCAVNGLLY VVGGDDGSCN LASVEYYNPT TDKWTVVSSC MSTGRSYAGV TVIDKPL 597 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |