CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030634
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-1 complex subunit gamma-1 
Protein Synonyms/Alias
 cDNA FLJ46199 fis, clone TESTI4007965, highly similar to AP-1 complex subunit gamma-1 
Gene Name
 AP1G1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52EEREMIQKECAAIRSacetylation[1]
52EEREMIQKECAAIRSubiquitination[2]
170GEVEKLLKTSNSYLRubiquitination[2]
190CAVHVIRKVPELMEMubiquitination[2]
345RFLLNNDKNIRYVALubiquitination[2]
385KDLDVSIKRRAMELSubiquitination[2, 3, 4]
569CTVNRIKKVVSIYGSubiquitination[3]
594VEYNALFKKYDHMRSubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 845 AA 
Protein Sequence
MEKNINLRNC QTLNTYVMLT HLRMPAPIRL RELIRTIRTA RTQAEEREMI QKECAAIRSS 60
FREEDNTYRC RNVAKLLYMH MLGYPAHFGQ LECLKLIASQ KFTDKRIGYL GAMLLLDERQ 120
DVHLLMTNCI KNDLNHSTQF VQGLALCTLG CMGSSEMCRD LAGEVEKLLK TSNSYLRKKA 180
ALCAVHVIRK VPELMEMFLP ATKNLLNEKN HGVLHTSVVL LTEMCERSPD MLAHFRKLVP 240
QLVRILKNLI MSGYSPEHDV SGISDPFLQV RILRLLRILG RNDDDSSEAM NDILAQVATN 300
TETSKNVGNA ILYETVLTIM DIKSESGLRV LAINILGRFL LNNDKNIRYV ALTSLLKTVQ 360
TDHNAVQRHR STIVDCLKDL DVSIKRRAME LSFALVNGNN IRGMMKELLY FLDSCEPEFK 420
ADCASGIFLA AEKYAPSKRW HIDTIMRVLT TAGSYVRDDA VPNLIQLITN SVEMHAYTVQ 480
RLYKAILGDY SQQPLVQVAA WCIGEYGDLL VSGQCEEEEP IQVTEDEVLD ILESVLISNM 540
STSVTRGYAL TAIMKLSTRF TCTVNRIKKV VSIYGSSIDV ELQQRAVEYN ALFKKYDHMR 600
SALLERMPVM EKVTTNGPTE IVQTNGETEP APLETKPPPS GPQPTSQAND LLDLLGGNDI 660
TPVIPTAPTS KPSSAGGELL DLLGDINLTG APAAAPAPAS VPQISQPPFL LDGLSSQPLF 720
NDIAAGIPSI TAYSKNGLKI EFTFERSNTN PSVTVITIQA SNSTELDMTD FVFQAAVPKT 780
FQLQLLSPSS SIVPAFNTGT ITQVIKVLNP QKQQLRMRIK LTYNHKGSAM QDLAEVNNFP 840
PQSWQ 845 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR017107; AP1_complex_gsu.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N.
 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR008153; Clathrin_g-adaptin_app.
 IPR013041; Coatomer/clathrin_app_Ig-like. 
Pfam
 PF01602; Adaptin_N
 PF02883; Alpha_adaptinC2 
SMART
 SM00809; Alpha_adaptinC2 
PROSITE
 PS50180; GAE 
PRINTS