UniProt Accession

 F5H1J9_HUMAN; F5H1J9 

Genbank Protein ID

 AL035470; AL356432; AL365224 

Genbank Nucleotide ID

  

Protein Name

 Protein THEMIS 

Protein Synonyms/Alias

  

Gene Name

 THEMIS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
92	LFKIVADKTPYLTME	ubiquitination	[1, 2, 3]
121	HPCFYHQKDIKLENL	ubiquitination	[2]
124	FYHQKDIKLENLIIK	ubiquitination	[1, 2, 3]
185	DERIYTLKEIVEWKI	ubiquitination	[2]
191	LKEIVEWKIPKNRTR	ubiquitination	[1, 2]
208	NLTDFSNKWDSTNPF	ubiquitination	[1, 2, 3]
239	QGVMKFRKDIIRILP	ubiquitination	[2, 3]
341	IPTSYKGKFKRRPRE	ubiquitination	[2]
359	AYDLEIAKSEKEPLH	ubiquitination	[2]
362	LEIAKSEKEPLHVVA	ubiquitination	[2, 3]
379	AFHSPHDKLSSVSVG	ubiquitination	[2]
415	VNVLACEKILKKSYE	ubiquitination	[2]
419	ACEKILKKSYEAALL	ubiquitination	[2]
442	VEVIHDKKQYPISEL	ubiquitination	[2]
451	YPISELCKQFRLPFN	ubiquitination	[2]
460	FRLPFNVKVSVRDLS	ubiquitination	[2]
583	ERTVDLPKSPKAGVQ	ubiquitination	[2]
586	VDLPKSPKAGVQWRD	ubiquitination	[2]
634	HHVDITKKLHPNQAG	ubiquitination	[1, 2]
645	NQAGLDSKVLIGSQN	ubiquitination	[2]
659	NDLVDEEKERSNRGA	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 680 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0043383; P:negative T cell selection; IEA:Compara.
 GO:0043368; P:positive T cell selection; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IEA:Compara. 

Interpro

 IPR025946; CABIT_dom. 

Pfam

 PF12736; CABIT 

SMART

  

PROSITE

  

PRINTS