Tag | Content |
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CPLM ID | CPLM-022550 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dynein heavy chain 1, axonemal |
Protein Synonyms/Alias | Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; Heat shock regulated protein 1; HSRF-1; hDHC7 |
Gene Name | DNAH1 |
Gene Synonyms/Alias | DHC7; DNAHC1; KIAA1410 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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1055 | IDAEQLEKNVVEAFK | ubiquitination | [1] | 2057 | SFVRSSVKEVIASTN | ubiquitination | [1] | 2073 | NLTMSLLKLLDCFFK | ubiquitination | [1] | 2080 | KLLDCFFKPFLPREG | ubiquitination | [1] | 2494 | SWFDQLLKRCMEQWE | ubiquitination | [1] | 2949 | QRPPPGVKLVIEAVC | ubiquitination | [1] | 2959 | IEAVCIMKGIKPKKV | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). |
Sequence Annotation | NP_BIND 1581 1588 ATP (Potential). NP_BIND 1862 1869 ATP (Potential). NP_BIND 2227 2234 ATP (Potential). NP_BIND 2586 2593 ATP (Potential). REGION 1 1542 Stem (By similarity). REGION 1543 1764 AAA 1 (By similarity). REGION 1824 2057 AAA 2 (By similarity). REGION 2189 2449 AAA 3 (By similarity). REGION 2547 2799 AAA 4 (By similarity). REGION 2814 3112 Stalk (By similarity). REGION 3262 3492 AAA 5 (By similarity). REGION 3705 3924 AAA 6 (By similarity). MOTIF 1581 1588 GPAGTGKT motif. MOTIF 1631 1637 CFDEFNR motif. |
Keyword | Alternative splicing; ATP-binding; Cell projection; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4330 AA |
Protein Sequence | MEQPNSKGYS LGRTPQGPEC SSAPAVQVGT HRGLEYNPGK ILPGSDYGLG NPPALDPKLP 60 HLPLPPAPPT LSDLGQPRKS PLTGTDKKYP LMKQRGFYSD ILSPGTLDQL GEVCRGPRMS 120 QNLLRQADLD KFTPRVGSFE VPEDFQERME QQCIGSTTRL LAQTDFPLQA YEPKMQVPFQ 180 VLPGQHPRKI EIERRKQQYL SLDIEQLLFS QGIDSNKLMP RHLDHQHPQT IEQGHDPIFP 240 IYLPLKVFDN EDFDCRTPRE WINMGLEPGS LDRKPVPGKA LLPTDDFLGH EDPKSQKLKY 300 KWCEVGVLDY DEEKKLYLVH KTDEKGLVRD EMGRPILNAG VTTEGRPPLQ VCQYWVPRIQ 360 LLFCAEDPCM FAQRVVQANA LRKNTEALLL YNLYVDCMPS DGQHVISEQS LSKIKQWALS 420 TPRMRKGPSV LEHLSSLARE VSLDYERSMN KINFDHVVSS KPETFSYVTL PKKEEEQVPE 480 RGLVSVPKYH FWEQKEDFTF VSLLTRPEVI TALSKVRAEC NKVTAMSLFH SSLSKYSHLE 540 EFEQIQSQTF SQVQMFLKDS WISSLKVAMR SSLRDMSKGW YNLYETNWEV YLMSKLRKLM 600 ELVKYMLQDT LRFLVQDSLA SFSQFISDTC CSVLNCTDDM VWGDDLINSP YRPRKNPLFI 660 MDLVLDSSGV HYSTPLEQFE ASLLNLFDKG ILATHAVPQL EKLVMEDIFI SGDPLLESVG 720 LHEPLVEELR ATIASAVSKA MIPLQAYAKE YRKYLELNNN DIASFLKTYQ TQGLLAQEVR 780 EVVLTHLREK EILDSSLPSS IIIGPFYINT DNVKQSLSKK RKALATSVLD ILAKNLHKEV 840 DSICEEFRSI SRKIYEKPNS IEELAELREW MKGIPERLVG LEERIVKVMD DYQVMDEFLY 900 NLSSDDFNDK WIASNWPSKI LGQIELVQQQ HVEDEEKFRK IQIMDQNNFQ EKLEGLQLVV 960 AGFSIHVEIS RAHEIANEVR RVKKQLKDCQ QLAMLYNNRE RIFSLPITNY DKLSRMVKEF 1020 QPYLDLWTTA SDWLRWSESW MNDPLSAIDA EQLEKNVVEA FKTMHKCVKQ FKDMPACQEV 1080 ALDIRARIEE FKPYIPLIQG LRNPGMRIRH WETLSNQINI NVRPKANLTF ARCLEMNLQD 1140 HIESISKVAE VAGKEYAIEQ ALDKMEKEWS TILFNVLPYK ATDTYILKSP DEASQLLDDH 1200 IVMTQNMSFS PYKKPFEQRI NSWENKLKLT QEVLEEWLNC QRSWLYLEPI FSSEDINQQL 1260 PVESKRYQTM ERIWKKIMKN AYENREVINV CSDLRMLDSL RDCNKILDLV QKGLSEYLET 1320 KRSAFPRFYF LSDDELLEIL SQTKDPTAVQ PHLRKCFENI ARLLFQEDLE ITHMYSAEGE 1380 EVQLCFSIYP SSNVEDWLRE VERSMKASVH DIIEKAIRAY PTMPRTQWVL NWPGQVTIAG 1440 CQTYWTMEVA EALEAGNLRS QLFPQLCQQL SDLVALVRGK LSRMQRAVLS ALIVIEVHAK 1500 DVVSKLIQEN VVSVNDFQWI SQLRYYWTNN DLYIRAVNAE FIYGYEYLGN SGRLVITPLT 1560 DRCYLTLTGA LHLKFGGAPA GPAGTGKTET TKDLGKALAI QTVVFNCSDQ LDFMAMGKFF 1620 KGLASAGAWA CFDEFNRIDI EVLSVVAQQI TTIQKAQQQR VERFMFEGVE IPLVPSCAVF 1680 ITMNPGYAGR TELPDNLKAL FRPVAMMVPD YAMITEISLY SFGFNEASVL AKKITTTFKL 1740 SSEQLSSQDH YDFGMRAVKT VISAAGNLKR ENPSMNEELI CLRAIRDVNV PKFLQEDLKL 1800 FSGIVSDLFP TIKEEDTDYG ILDEAIREAC RNSNLKDVEG FLTKCIQLYE TTVVRHGLML 1860 VGPTGSGKST CYRVLAAAMT SLKGQPSISG GMYEAVNYYV LNPKSITMGQ LYGEFDLLTH 1920 EWTDGIFSSF IRAGAITSDT NKKWYMFDGP VDAIWIENMN TVLDDNKKLC LSSGEIIKLT 1980 EAMTMMFEVQ DLAVASPATV SRCGMVYLEP SILGLMPFIE CWLRKLPPLL KPYEEHFKAL 2040 FVSFLEESIS FVRSSVKEVI ASTNCNLTMS LLKLLDCFFK PFLPREGLKK IPSEKLSRIV 2100 ELIEPWFIFS LIWSVGATGD SSGRTSFSHW LRLKMENEQL TLLFPEEGLV FDYRLEDAGI 2160 SGTNDSEDEE EEYKQVAWVK WMDSSAPFTM VPDTNYCNII VPTMDTVQMS HLLDMLLTNK 2220 KPVLCIGPTG TGKTLTISDK LLKNLALDYI SHFLTFSART SANQTQDFID SKLDKRRKGV 2280 FGPPLGRNFI FFIDDLNMPA LETYGAQPPI ELLRQWMDHG GWYDRKIIGA FKNLVDINFV 2340 CAMGPPGGGR NTVTPRLMRH FNYLSFAEMD EVSKKRIFST ILGNWLDGLL GEKSYRERVP 2400 GAPHIAHFTE PLVEATIMVY ATITSQLLPT PAKSHYTFNL RDLSKVFQGM LMADPAKVED 2460 QVQLLRLWYH ENCRVFRDRL VNEEDRSWFD QLLKRCMEQW EVTFNKVCPF QPILYGDFMS 2520 PGSDVKSYEL ITSESKMMQV IEEYIEDYNQ INTAKLKLVL FMDAMSHICR ISRTLRQALG 2580 NALLLGVGGS GRSSLTRLAS HMAEYECFQI ELSKNYGMSE WRDDVKKVLL KAGLQNLPIT 2640 FLFSDTQIKN ESFLEDINNV LNSGDIPNLY TADEQDQIVS TMRPYIQEQG LQPTKANLMA 2700 AYTGRVRSNI HMVLCMSPIG EVFRARLRQF PSLVNCCTID WFNEWPAEAL KSVATVFLNE 2760 IPELESSQEE IQGLIQVCVY IHQSVSKKCI EYLAELTRHN YVTPKSYLEL LHIFSILIGQ 2820 KKLELKTAKN RMKSGLDKLL RTSEDVAKMQ EDLESMHPLL EEAAKDTMLT MEQIKVDTAI 2880 AEETRNSVQT EEIKANEKAK KAQAIADDAQ KDLDEALPAL DAALASLRNL NKNDVTEVRA 2940 MQRPPPGVKL VIEAVCIMKG IKPKKVPGEK PGTKVDDYWE PGKGLLQDPG HFLESLFKFD 3000 KDNIGDVVIK AIQPYIDNEE FQPATIAKVS KACTSICQWV RAMHKYHFVA KAVEPKRQAL 3060 LEAQDDLGVT QRILDEAKQR LREVEDGIAT MQAKYRECIT KKEELELKCE QCEQRLGRAG 3120 KVRTLLLQGL QAGPAQTGAR KDQGAGGSWG GCPHPLPGNP GATVGRASPR PLAQPPRAHP 3180 TGLPLQLING LSDEKVRWQE TVENLQYMLN NISGDVLVAA GFVAYLGPFT GQYRTVLYDS 3240 WVKQLRSHNV PHTSEPTLIG TLGNPVKIRS WQIAGLPNDT LSVENGVINQ FSQRWTHFID 3300 PQSQANKWIK NMEKDNGLDV FKLSDRDFLR SMENAIRFGK PCLLENVGEE LDPALEPVLL 3360 KQTYKQQGNT VLKLGDTVIP YHEDFRMYIT TKLPNPHYTP EISTKLTLIN FTLSPSGLED 3420 QLLGQVVAEE RPDLEEAKNQ LIISNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL 3480 EASKMKAAEI QAKVRIAEQT EKDIDLTRME YIPVAIRTQI LFFCVSDLAN VDPMYQYSLE 3540 WFLNIFLSGI ANSERADNLK KRISNINRYL TYSLYSNVCR SLFEKHKLMF AFLLCVRIMM 3600 NEGKINQSEW RYLLSGGSIS IMTENPAPDW LSDRAWRDIL ALSNLPTFSS FSSDFVKHLS 3660 EFRVIFDSLE PHREPLPGIW DQYLDQFQKL LVLRCLRGDK VTNAMQDFVA TNLEPRFIEP 3720 QTANLSVVFK DSNSTTPLIF VLSPGTDPAA DLYKFAEEMK FSKKLSAISL GQGQGPRAEA 3780 MMRSSIERGK WVFFQNCHLA PSWMPALERL IEHINPDKVH RDFRLWLTSL PSNKFPVSIL 3840 QNGSKMTIEP PRGVRANLLK SYSSLGEDFL NSCHKVMEFK SLLLSLCLFH GNALERHKFG 3900 PLGFNIPYEF TDGDLRICIS QLKMFLDEYD DIPYKVLKYT AGEINYGGRV TDDWDRRCIM 3960 NILEDFYNPD VLSPEHSYSA SGIYHQIPPT YDLHGYLSYI KSLPLNDMPE IFGLHDNANI 4020 TFAQNETFAL LGTIIQLQPK SSSAGSQGRE EIVEDVTQNI LLKVPEPINL QWVMAKYPVL 4080 YEESMNTVLV QEVIRYNRLL QVITQTLQDL LKALKGLVVM SSQLELMAAS LYNNTVPELW 4140 SAKAYPSLKP LSSWVMDLLQ RLDFLQAWIQ DGIPAVFWIS GFFFPQAFLT GTLQNFARKF 4200 VISIDTISFD FKVPAGIQRP SSWLSLSPRS CTQRWPLSGS CQHPTARPRT RTFTCAPSTR 4260 H 4261 |
Gene Ontology | GO:0005858; C:axonemal dynein complex; NAS:UniProtKB. GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016887; F:ATPase activity; IEA:InterPro. GO:0003777; F:microtubule motor activity; NAS:UniProtKB. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0001539; P:ciliary or flagellar motility; NAS:UniProtKB. GO:0007018; P:microtubule-based movement; IEA:Compara. GO:0009612; P:response to mechanical stimulus; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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