UniProt Accession

 G3UWD2_MOUSE; G3UWD2 

Genbank Protein ID

 AL672278; CT025774; CH466602 

Genbank Nucleotide ID

 EDL03777.1 

Protein Name

 Runt related transcription factor 1, isoform CRA_c 

Protein Synonyms/Alias

 Runt-related transcription factor 1 

Gene Name

 Runx1 

Gene Synonyms/Alias

 mCG_13559 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	STALSPGKMSEALPL	acetylation	[1, 2]
43	GGAALASKLRSGDRS	acetylation	[1, 2, 3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 451 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0048266; P:behavioral response to pain; IMP:MGI.
 GO:0007417; P:central nervous system development; IMP:MGI.
 GO:0060216; P:definitive hemopoiesis; IMP:MGI.
 GO:0035162; P:embryonic hemopoiesis; IMP:MGI.
 GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0002318; P:myeloid progenitor cell differentiation; IMP:MGI.
 GO:0048666; P:neuron development; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0071336; P:regulation of hair follicle cell proliferation; IMP:MGI.
 GO:0009966; P:regulation of signal transduction; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI. 

Interpro

 IPR000040; AML1_Runt.
 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR013524; Runt_dom.
 IPR027384; Runx_central_dom.
 IPR013711; RunxI_C_dom.
 IPR016554; TF_Runt-rel_RUNX. 

Pfam

 PF00853; Runt
 PF08504; RunxI 

SMART

  

PROSITE

 PS51062; RUNT 

PRINTS

 PR00967; ONCOGENEAML1.