CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase receptor 
Protein Synonyms/Alias
  
Gene Name
 Kit 
Gene Synonyms/Alias
 KIT; rCG_56893 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
927QVVQLIEKQISDSSKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 978 AA 
Protein Sequence
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA GDTIRLTCTD 60
PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG SGLRSSIYVF VRDPAVLFLV 120
GLPLFGKEDN DALVRCPLTD PQVSNYSLIE CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH 180
RLCIRCAAQR EGKWMRSDKF TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST 240
SVDSMWIKLN PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS 300
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW IYMNRTPTNR 360
GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD VSASVTFDVY VNTKPEILTY 420
DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ RCTVPVPPVD VQIQNASVSP FGKLVVQSSI 480
DSSVFRHNGT VECKASNAVG KSSAFFNFAF KGNSKEQIQP HTLFTPLLIG FVVTAGLMGI 540
IVMVLAYKYL QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG 600
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG NHMNIVNLLG 660
ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA DAALYKNLLH SKESSCDSSN 720
EYMDMKPGVS YVVPTKTDKR RSARIDSYIE RDVTPAIMED DELALDLEDL LSFSYQVAKG 780
MAFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA RLPVKWMAPE 840
SIFNCVYTFE SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAAM 900
YEVMKTCWDA DPLKRPTFKQ VVQLIEKQIS DSSKHIYSNL ANCNPNPENP VVVDHSVRVN 960
SVGSSTSSTQ PLLVHEDA 978 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IDA:RGD.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0009898; C:internal side of plasma membrane; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; IEA:InterPro.
 GO:0005020; F:stem cell factor receptor activity; IEA:Compara.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IDA:RGD.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Compara.
 GO:0002371; P:dendritic cell cytokine production; IEA:Compara.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Compara.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0050673; P:epithelial cell proliferation; IMP:RGD.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0038162; P:erythropoietin-mediated signaling pathway; IEA:Compara.
 GO:0038093; P:Fc receptor signaling pathway; IEA:Compara.
 GO:0008354; P:germ cell migration; IMP:RGD.
 GO:0035234; P:germ cell programmed cell death; IEA:Compara.
 GO:0006687; P:glycosphingolipid metabolic process; IEA:Compara.
 GO:0002327; P:immature B cell differentiation; IEA:Compara.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0002551; P:mast cell chemotaxis; IEA:Compara.
 GO:0032762; P:mast cell cytokine production; IEA:Compara.
 GO:0043303; P:mast cell degranulation; IEA:Compara.
 GO:0060374; P:mast cell differentiation; IEA:Compara.
 GO:0035855; P:megakaryocyte development; IEA:Compara.
 GO:0097326; P:melanocyte adhesion; IEA:Compara.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0097324; P:melanocyte migration; IEA:Compara.
 GO:0002318; P:myeloid progenitor cell differentiation; IEA:Compara.
 GO:0043069; P:negative regulation of programmed cell death; IEA:Compara.
 GO:0001541; P:ovarian follicle development; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.
 GO:0030335; P:positive regulation of cell migration; IMP:RGD.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IMP:RGD.
 GO:0045747; P:positive regulation of Notch signaling pathway; IMP:RGD.
 GO:0031274; P:positive regulation of pseudopodium assembly; IMP:RGD.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IEA:Compara.
 GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Compara.
 GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IDA:RGD.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0048070; P:regulation of developmental pigmentation; IEA:Compara.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0048103; P:somatic stem cell division; IMP:RGD.
 GO:0035019; P:somatic stem cell maintenance; IMP:RGD.
 GO:0007286; P:spermatid development; IEA:Compara.
 GO:0007283; P:spermatogenesis; IMP:RGD.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0008542; P:visual learning; IMP:RGD. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR027263; SCGF_receptor.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
 IPR001824; Tyr_kinase_rcpt_3_CS. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 
PRINTS