CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023581
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable glutamine--tRNA ligase 
Protein Synonyms/Alias
 Glutaminyl-tRNA synthetase; GlnRS 
Gene Name
 Aats-gln 
Gene Synonyms/Alias
 CG10506 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
312YDDTNPEKEEEKFFLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 MOTIF 273 283 "HIGH" region.
 MOTIF 496 500 "KMSKS" region.
 BINDING 499 499 ATP (By similarity).  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 778 AA 
Protein Sequence
MAGDDLIAKF QALGMSEQKA KETLKNANVT KNLQLSLAAA GSATLSDGTG MLIYHMATKL 60
KPQTADHLPL LVRYIVEHKL DNTQRVDAAL EYLLKCGQSL NANIDLQALE KECGVGVVVT 120
PEQIERTVQA KIKASYKEAL LEQRYHFNSF KILQDVRGEL KWADAKSVKA AIDVEIFDLL 180
GPKTEADLKP QTKANDKPKA AKPKAEVTPA AQTAEAASDG ATTISELMKT KVHFHAPGEN 240
FKADGYVVTE HTERLLKEHL ARTGGKVHTR FPPEPNGILH IGHAKAININ FGYAAAHDGV 300
CYLRYDDTNP EKEEEKFFLA IKEMVEWLGY KPFKITYSSD NFQQLYEWAV VLINKGLAYV 360
CHQKAEELKG FNPKPSPWRE RPIEESLRLF EDMKRGKIDE GAATLRMKVT LEEGKMDPVA 420
YRIKFISHHR TGSDWCIYPT YDYTHCLCDS LEDITHSLCT KEFQSRRSSY YWLCNALGIY 480
CPVQWEYGRL NMNYALVSKR KIAKLITEQI VHDWDDPRLF TLTALRRRGF PAEAINNFCA 540
QMGVTGAQIA VDPAMLEAAV RDVLNVTAPR RLVVLEPLKV TIKNFPHAAP VQLEVPDFPQ 600
NPQQGTHKIT LDKVIYIEQG DFKLEPEKGY RRLAPKQSVG LRHAGLVISV DEIVKDPATG 660
QVVELICTSQ PAEQAEKPKA FVQWVSQPIQ LEVRLYEQLF KHKNPEDPNE VPGGFLSDIS 720
EQSMSVVVAF ADRALNQAKV YDKFQFERIG FFSVDPDTSA NHLVFNRTVG LKEDAGKK 778 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004819; F:glutamine-tRNA ligase activity; ISS:FlyBase.
 GO:0006425; P:glutaminyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR001412; aa-tRNA-synth_I_CS.
 IPR004514; Gln-tRNA-synth_Ib.
 IPR007638; Gln-tRNA-synth_Ib_RNA-bd_2.
 IPR007639; Gln-tRNA-synth_Ib_RNA-bd_N.
 IPR000924; Glu/Gln-tRNA-synth_Ib.
 IPR020061; Glu/Gln-tRNA-synth_Ib_a-bdl.
 IPR020058; Glu/Gln-tRNA-synth_Ib_cat-dom.
 IPR020059; Glu/Gln-tRNA-synth_Ib_codon-bd.
 IPR020056; Rbsml_L25/Gln-tRNA_synth_b-brl.
 IPR011035; Ribosomal_L25/Gln-tRNA_synth.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00749; tRNA-synt_1c
 PF03950; tRNA-synt_1c_C
 PF04558; tRNA_synt_1c_R1
 PF04557; tRNA_synt_1c_R2 
SMART
  
PROSITE
 PS00178; AA_TRNA_LIGASE_I 
PRINTS
 PR00987; TRNASYNTHGLU.