UniProt Accession

 FOLR1_HUMAN; P15328; Q53EW2; Q6FGT8; Q6LC90; Q9UCT2 

Genbank Protein ID

 J05013; M28099; X62753; U20391; U78793; U78794; BT007158; CR542019; AK223527; CH471076; BC002947; M25317 

Genbank Nucleotide ID

 AAA35823.1; AAA35822.1; CAA44610.1; AAB05827.1; AAB39751.1; AAB39752.1; AAP35822.1; CAG46816.1; BAD97247.1; EAW74848.1; AAH02947.1; AAA74896.1 

Protein Name

 Folate receptor alpha 

Protein Synonyms/Alias

 FR-alpha; Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor, adult; KB cells FBP; Ovarian tumor-associated antigen MOv18 

Gene Name

 FOLR1 

Gene Synonyms/Alias

 FOLR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	GEMAPACKRHFIQDT	ubiquitination	[1]
136	VLNVPLCKEDCEQWW	ubiquitination	[1, 2]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. 

Sequence Annotation

 LIPID 234 234 GPI-anchor amidated serine.
 CARBOHYD 69 69 N-linked (GlcNAc...) (By similarity).
 CARBOHYD 161 161 N-linked (GlcNAc...).
 CARBOHYD 201 201 N-linked (GlcNAc...).  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Folate-binding; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Neurodegeneration; Polymorphism; Receptor; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 257 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005542; F:folic acid binding; NAS:UniProtKB.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0046655; P:folic acid metabolic process; IEA:Compara.
 GO:0015884; P:folic acid transport; TAS:ProtInc.
 GO:0006898; P:receptor-mediated endocytosis; TAS:ProtInc. 

Interpro

 IPR004269; Folate_rcpt.
 IPR018143; Folate_rcpt-like. 

Pfam

 PF03024; Folate_rec 

SMART

  

PROSITE

  

PRINTS