| Tag | Content |
|---|
| CPLM ID | CPLM-000499 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent protease ATPase subunit HslU |
Protein Synonyms/Alias | Heat shock protein HslU; Unfoldase HslU |
Gene Name | hslU |
Gene Synonyms/Alias | STM4091 |
Created Date | July 27, 2013 |
Organism | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
NCBI Taxa ID | 99287 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 63 | IGPTGVGKTEIARRL | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity). |
Sequence Annotation | NP_BIND 60 65 ATP (By similarity).
BINDING 18 18 ATP; via amide nitrogen and carbonyl
BINDING 256 256 ATP (By similarity).
BINDING 321 321 ATP (By similarity).
BINDING 393 393 ATP (By similarity). |
Keyword | ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 443 AA |
Protein Sequence | MSEMTPREIV SELNKHIIGQ DNAKRSVAIA LRNRWRRMQL DEELRHEVTP KNILMIGPTG 60
VGKTEIARRL AKLANAPFIK VEATKFTEVG YVGKEVDSII RDLTDAAVKM VRVQAIEKNR 120
YRAEELAEER ILDVLIPPAK NNWGQAEQQQ EPSAARQTFR KKLREGQLDD KEIEINLAAA 180
PMGVEIMAPP GMEEMTSQLQ SMFQNLGGQK QKPRKLKIKD AMKLLVEEEA AKLVNPEELK 240
QDAIDAVEQH GIVFIDEIDK ICKRGETSGP DVSREGVQRD LLPLVEGCTV STKHGMVKTD 300
HILFIASGAF QVAKPSDLIP ELQGRLPIRV ELQALTTSDF ERILTEPNAS VTVQYKALMA 360
TEGVNIEFTD SGIKRIAEAA WQVNETTENI GARRLHTVLE RLMEEISYNA SDLHGQNITI 420
DAEYVSKHLD ALVADEDLSR FIL 443 |
Gene Ontology | GO:0009376; C:HslUV protease complex; IEA:HAMAP. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0016887; F:ATPase activity; IEA:HAMAP. GO:0070011; F:peptidase activity, acting on L-amino acid peptides; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. GO:0043335; P:protein unfolding; IEA:HAMAP. GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
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PROSITE | |
PRINTS | |