| Tag | Content |
|---|
| CPLM ID | CPLM-001423 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 22 member 8 |
Protein Synonyms/Alias | Organic anion transporter 3; mOat3; Reduced in osteosclerosis transporter |
Gene Name | Slc22a8 |
Gene Synonyms/Alias | Oat3; Roct |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 291 | GKKEEGEKLTVEELK | ubiquitination | [1] | | 298 | KLTVEELKFNLQKDI | ubiquitination | [1] | | 303 | ELKFNLQKDITSAKV | ubiquitination | [1] | | 311 | DITSAKVKYGLSDLF | ubiquitination | [1] | | 525 | KQEPEAEKASQTIPL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine. |
Sequence Annotation | CARBOHYD 81 81 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Detoxification; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 537 AA |
Protein Sequence | MTFSEILDRV GSMGPFQYLH VTLLALPILG IANHNLLQIF TATTPDHHCR PPPNASLEPW 60
VLPLGPNGKP EKCLRFVHLP NASLPNDTQG ATEPCLDGWI YNSTRDTIVT EWDLVCGSNK 120
LKEMAQSVFM AGILVGGPVF GELSDRFGRK PILTWSYLLL AASGSSAAFS PSLTVYMIFR 180
FLCGCSISGI SLSTIILNVE WVPTSTRAIS STTIGYCYTI GQFILPGLAY AVPQWRWLQL 240
SVSAAFFIFS LLSWWVPESI RWLVLSGKFS KALKTLQRVA TFNGKKEEGE KLTVEELKFN 300
LQKDITSAKV KYGLSDLFRV SILRRVTFCL SLAWFATGFA YYSLAMGVEE FGVNIYILQI 360
IFGGVDIPAK FITILSISYL GRRITQGFLL ILAGVAILAL IFVSSEMQLL RTALAVFGKG 420
CLSGSFSCLF LYTSELYPTV LRQTGMGISN IWARVGSMIA PLVKITGELQ PFIPNVIFGT 480
MTLLGGSAAF FLLETLNRPL PETIEDIQDW YQQTKKTKQE PEAEKASQTI PLKTGGP 537 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005452; F:inorganic anion exchanger activity; IEA:Compara. GO:0008514; F:organic anion transmembrane transporter activity; IEA:Compara. GO:0015651; F:quaternary ammonium group transmembrane transporter activity; IEA:Compara. GO:0034635; P:glutathione transport; IEA:Compara. GO:0031427; P:response to methotrexate; IEA:Compara. GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |