CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013158
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 2 oral 
Protein Synonyms/Alias
 Keratin-76; K76; Type-II keratin Kb9 
Gene Name
 Krt76 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
351QYEDIAQKSKAEAEAacetylation[1]
351QYEDIAQKSKAEAEAsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Probably contributes to terminal cornification (By similarity). 
Sequence Annotation
 REGION 1 164 Head.
 REGION 165 476 Rod.
 REGION 165 200 Coil 1A.
 REGION 201 221 Linker 1.
 REGION 222 313 Coil 1B.
 REGION 314 337 Linker 12.
 REGION 338 476 Coil 2.
 REGION 477 594 Tail.  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Keratin; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MSRQACKKSF SCGSQGFSGH SAVVSGSSRS SCVARSGAAS GGACGFRSGA GSLGSHSLYS 60
LGGSKSISIS VAAGGSRAGG FSGGRSSCGS GFGSGYGGSL GGSRGMGAGF GGPSGFGGAG 120
GFGRPGSFGP GSCPGGIQEV TINQSLLQPL NVEIDPQIGQ VKAQEREQIK TLNNKFASFI 180
DKVRFLEQQN KVLETKWELL QQQTIRSGSG PQNLEPFFES YISCLRKQLD SLLGAKGSLE 240
GELKSMQDLV EDFKKKYEEE INRRTAAENE FVGLKKDVDG AFMNKVELQA KVDSLTDEIN 300
FLRTLYDMEL SQIQSHVSDT SVVLSMDNNR CLDLDSIIAE VKAQYEDIAQ KSKAEAEALY 360
QTKLGELQTT AGRHGDDLRS TKSEIMDLNR MIQRLRAEIE NVKKQNTNMQ TSIAEAEQRG 420
ERALKDADTK FQDLQVALQK AKEDMARLLK EYQELMNVKL ALDVEIATYR KLLEGEECRL 480
SGEFQNAVSI SVVSNVTSTS SSGSFRGTGG SNYGGDSSGR SGGSSSSSSR GSSSRGSSGS 540
RLGSGGSISV SQQRMGFNSG GSQTSVGSSY KSGRGGSSSV QFSQTTSSSQ QRSK 594 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.