CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013087
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plexin-D1 
Protein Synonyms/Alias
  
Gene Name
 Plxnd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1352GIPFLEYKHFVTRTFubiquitination[1]
1657LAMSLTDKKDSTLGRubiquitination[1]
1672VKDLDTEKYFHLVLPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature. 
Sequence Annotation
 DOMAIN 49 548 Sema.
 DOMAIN 893 977 IPT/TIG 1.
 DOMAIN 983 1065 IPT/TIG 2.
 DOMAIN 1071 1145 IPT/TIG 3.
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
 CARBOHYD 226 226 N-linked (GlcNAc...) (Potential).
 CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).
 CARBOHYD 967 967 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1120 1120 N-linked (GlcNAc...) (Potential).
 DISULFID 106 116 By similarity.
 DISULFID 142 150 By similarity.
 DISULFID 324 447 By similarity.
 DISULFID 347 391 By similarity.
 DISULFID 551 568 By similarity.
 DISULFID 557 602 By similarity.
 DISULFID 560 577 By similarity.
 DISULFID 571 583 By similarity.
 DISULFID 639 663 By similarity.  
Keyword
 Angiogenesis; Cell membrane; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1925 AA 
Protein Sequence
MARRAAGGAP PSARAAAAVP LRPRPHSRGP GLLPLPLLLL LGAARAGALE IQRRFPSPTP 60
TNNFALDGTA GTVYLAAVNR LYQLSSANLS LEAEATVGPV PDSPLCHAPQ LPQASCEHPR 120
RLTDNYNKIL QLDPGQGLVV ACGSIYQGLC QLRRRGNISA LAVSFPPAAP TAEPVTVFPS 180
MLNVAANHPN ASTVGLVLPP TSGTGGSRLL VGATYTGFGS AFFPRNRSLE DHRFENTPEI 240
AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPAV PPHSAQPYAY 300
LALNSEARAG DKDSQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL 360
VSVFPAREQF FAVFERPQGA PGARNAPAAL CAFRFDDVQA AIRAARTACF VEPAPDVVAV 420
LDSVVQGTGP ACESKRNIQL QPEQLDCGAA HLQHPLTILQ PLRASPVFRA PGLTAVAVAS 480
ANNYTAVFLG TATGRLLKIS LNESMQVVSR RVLTVAYGEP VHHVMQFDPM DPGYLYLMTS 540
HQMARVKVAA CEVHSTCGDC VGAADAYCGW CTLETRCTLQ QDCTNSSQPH FWTSASEGPS 600
RCPAMTVLPS EIDVHRDYTG MILQISGSLP SLSGMEMACD YGNGVRTVAR VPGPAYDHQI 660
AYCNLLPRAQ FPSFPAGQDH VTVEMSVRVK GHNIVSANFT IYDCSRIGQV YPHTACTSCL 720
STQWPCSWCI QLHSCVSNQS QCQDSPNPTS PQDCPQILPS PLAPVPTGGS QDILVPLTKA 780
TFFHGSSLEC SFGLEESFEA VWANNSLVRC NQVVLHTTQK SQVFPLSLKL KGPPDRFLDS 840
PNPMTVVVYN CAMGSPDCSQ CLGREDLGHL CVWNDGCRLR GPLQPLPGTC PAPEIRAIEP 900
LSGPLDGGTL LTIRGRNLGR RLSDVAHGVW IGSVACEPLA DRYTVSEEIV CATGPAAGAF 960
SDVVTVNVSK EGRSREQFSY VLPTVHSLEP SMGPKAGGTR ITIHGSDLNV GSMLQVLVND 1020
TDPCTDLTRT ATSITCTVPG GTLPSPVPVC VRFESRGCVH GNLTFWYMQN PVITAISPGR 1080
SPVSGGRTIT VAGERFHMVQ NVSMAVHHIG REPTFCKVLN STLITCPSPG ALSNASAPVD 1140
FFINGRAYAD EAAEELLDPA EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH 1200
KEQDSLGLES HEYHIKIGQV SCDIQIISDR VIHCSVNESL GTAEGQLPIT IQVGNFNQTI 1260
ATLQLGGSET AIVVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE 1320
EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSKTLNS 1380
QGGSPPQETH PLLGEWNIPE HCRPSMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD 1440
RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI 1500
CMYGCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LNEEWLLREN IEAKPRNLNV 1560
SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYVL 1620
RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLTDKKDS TLGRVKDLDT EKYFHLVLPT 1680
DELVEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF 1740
FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIEKTDH IDACLSVIAQ 1800
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKTVQRYYK QIQDMTPLSE QEMNAHLAEE 1860
SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMENNIYE 1920
CYSEA 1925 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0017154; F:semaphorin receptor activity; IDA:UniProtKB.
 GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IDA:MGI.
 GO:0043542; P:endothelial cell migration; IMP:UniProtKB.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0045765; P:regulation of angiogenesis; IMP:UniProtKB.
 GO:0030334; P:regulation of cell migration; IMP:UniProtKB.
 GO:0007416; P:synapse assembly; IMP:UniProtKB. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR013548; Plexin_cytoplasmic_RasGAP_dom.
 IPR002165; Plexin_repeat.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001627; Semaphorin/CD100_Ag.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08337; Plexin_cytopl
 PF01437; PSI
 PF01403; Sema
 PF01833; TIG 
SMART
 SM00429; IPT
 SM00423; PSI
 SM00630; Sema 
PROSITE
 PS51004; SEMA 
PRINTS