CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat and calponin homology domain-containing protein 4 
Protein Synonyms/Alias
 Leucine-rich repeat neuronal protein 4; Leucine-rich neuronal protein 
Gene Name
 LRCH4 
Gene Synonyms/Alias
 LRN; LRRN1; LRRN4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
147VLIVSNNKLGALPPDubiquitination[1]
249PPAQVCLKGKLHIFKubiquitination[1]
251AQVCLKGKLHIFKYLubiquitination[1]
256KGKLHIFKYLSTEAGubiquitination[1]
310HSVDSGSKRWSGNESubiquitination[1]
602LSALKARKNVESFLEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 43 64 LRR 1.
 REPEAT 69 90 LRR 2.
 REPEAT 92 114 LRR 3.
 REPEAT 115 136 LRR 4.
 REPEAT 137 158 LRR 5.
 REPEAT 160 182 LRR 6.
 REPEAT 183 205 LRR 7.
 REPEAT 206 226 LRR 8.
 REPEAT 228 249 LRR 9.
 DOMAIN 534 649 CH.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 517 517 Phosphoserine.
 MOD_RES 521 521 Phosphoserine.  
Keyword
 Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 683 AA 
Protein Sequence
MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG 60
AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN 120
LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG 180
LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ 240
SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS 300
GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH 360
VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ 420
QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS 480
QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL 540
MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA 600
RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL PPLWPPSGLG 660
GFVVFYVVLM LLLYVTYTRL LGS 683 
Gene Ontology
 GO:0016605; C:PML body; IDA:MGI.
 GO:0007399; P:nervous system development; TAS:ProtInc. 
Interpro
 IPR001715; CH-domain.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp. 
Pfam
 PF00307; CH
 PF00560; LRR_1 
SMART
 SM00033; CH
 SM00369; LRR_TYP 
PROSITE
 PS50021; CH
 PS51450; LRR 
PRINTS