UniProt Accession

 CLIC2_HUMAN; O15247; A8K9S0; O15174; Q5JT80; Q8TCE3 

Genbank Protein ID

 Y12696; AJ000217; AJ000218; AJ000219; AK292785; AL356738; CH471172; BC022305 

Genbank Nucleotide ID

 CAA73228.1; CAA03948.1; CAA03948.1; CAA03948.1; BAF85474.1; CAI41464.1; EAW72624.1; AAH22305.1 

Protein Name

 Chloride intracellular channel protein 2 

Protein Synonyms/Alias

 XAP121 

Gene Name

 CLIC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
194	LPKLNIIKVAAKKYR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. 

Sequence Annotation

 DOMAIN 99 239 GST C-terminal.
 REGION 1 96 Required for insertion into the membrane
 REGION 1 94 N-terminal.
 REGION 95 106 Joint loop.
 REGION 107 247 C-terminal.
 REGION 151 171 Foot loop.
 DISULFID 30 33 In soluble form.  

Keyword

 3D-structure; Chloride; Chloride channel; Complete proteome; Cytoplasm; Disease mutation; Disulfide bond; Ion channel; Ion transport; Membrane; Mental retardation; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0005634; C:nucleus; TAS:UniProtKB.
 GO:0005254; F:chloride channel activity; TAS:ProtInc.
 GO:0004602; F:glutathione peroxidase activity; IDA:BHF-UCL.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0060315; P:negative regulation of ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0051099; P:positive regulation of binding; IDA:BHF-UCL.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IC:BHF-UCL. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS

 PR01263; INTCLCHANNEL.