CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022115
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LanC-like protein 2 
Protein Synonyms/Alias
 Testis-specific adriamycin sensitivity protein 
Gene Name
 LANCL2 
Gene Synonyms/Alias
 GPR69B; TASP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
164VGAVIYHKLRSDCESubiquitination[1, 2, 3]
290ETLTEMVKPSIDYVRubiquitination[4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. 
Sequence Annotation
 REGION 2 15 Interaction with inositol phospholipids.
 MOD_RES 198 198 Phosphotyrosine (By similarity).
 MOD_RES 259 259 Phosphotyrosine (By similarity).
 MOD_RES 295 295 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine.  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Lipoprotein; Membrane; Myristate; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MGETMSKRLK LHLGGEAEME ERAFVNPFPD YEAAAGALLA SGAAEETGCV RPPATTDEPG 60
LPFHQDGKII HNFIRRIQTK IKDLLQQMEE GLKTADPHDC SAYTGWTGIA LLYLQLYRVT 120
CDQTYLLRSL DYVKRTLRNL NGRRVTFLCG DAGPLAVGAV IYHKLRSDCE SQECVTKLLQ 180
LQRSVVCQES DLPDELLYGR AGYLYALLYL NTEIGPGTVC ESAIKEVVNA IIESGKTLSR 240
EERKTERCPL LYQWHRKQYV GAAHGMAGIY YMLMQPAAKV DQETLTEMVK PSIDYVRHKK 300
FRSGNYPSSL SNETDRLVHW CHGAPGVIHM LMQAYKVFKE EKYLKEAMEC SDVIWQRGLL 360
RKGYGICHGT AGNGYSFLSL YRLTQDKKYL YRACKFAEWC LDYGAHGCRI PDRPYSLFEG 420
MAGAIHFLSD VLGPETSRFP AFELDSSKRD 450 
Gene Ontology
 GO:0030864; C:cortical actin cytoskeleton; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0005525; F:GTP binding; NAS:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.
 GO:0070273; F:phosphatidylinositol-4-phosphate binding; IDA:UniProtKB.
 GO:0010314; F:phosphatidylinositol-5-phosphate binding; IDA:UniProtKB.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0009789; P:positive regulation of abscisic acid mediated signaling pathway; IDA:UniProtKB. 
Interpro
 IPR008928; 6-hairpin_glycosidase-like.
 IPR012341; 6hp_glycosidase.
 IPR007822; LANC-like.
 IPR020464; LanC-like_prot_euk. 
Pfam
 PF05147; LANC_like 
SMART
  
PROSITE
  
PRINTS
 PR01951; LANCEUKARYTE.
 PR01950; LANCSUPER.