UniProt Accession

 PMGE_MOUSE; P15327; Q543Z6 

Genbank Protein ID

 X13586; AK043412; AK078119; BC004589 

Genbank Nucleotide ID

 CAA31927.1; BAC31541.1; BAC37133.1; AAH04589.1 

Protein Name

 Bisphosphoglycerate mutase 

Protein Synonyms/Alias

 BPGM; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM 

Gene Name

 Bpgm 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
5	***MSKHKLIILRHG	ubiquitination	[1]
29	FCSWVDQKLNNDGLE	ubiquitination	[1]
102	LIGLNREKMALNHGE	ubiquitination	[1]
143	IYSDRRYKVCDVPLD	ubiquitination	[1]
170	ERLLPYWKERIAPEI	ubiquitination	[1]
179	RIAPEILKGKSILIS	ubiquitination	[1]
181	APEILKGKSILISAH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. 

Sequence Annotation

 REGION 23 24 2,3-bisphospho-D-glycerate binding (By
 REGION 89 92 2,3-bisphospho-D-glycerate binding (By
 REGION 116 117 2,3-diphosphoglyceric acid binding (By
 REGION 188 190 2,3-bisphospho-D-glycerate binding (By
 ACT_SITE 11 11 Tele-phosphohistidine intermediate (By
 ACT_SITE 188 188 By similarity.
 BINDING 17 17 2,3-bisphospho-D-glycerate (By
 BINDING 62 62 2,3-bisphospho-D-glycerate (By
 BINDING 100 100 2,3-bisphospho-D-glycerate (By  

Keyword

 Complete proteome; Glycolysis; Hydrolase; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 259 AA 

Protein Sequence

Gene Ontology

 GO:0004083; F:bisphosphoglycerate 2-phosphatase activity; IEA:EC.
 GO:0004082; F:bisphosphoglycerate mutase activity; IEA:EC.
 GO:0004619; F:phosphoglycerate mutase activity; IEA:EC.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 

Interpro

 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS.
 IPR005952; Phosphogly_mut1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS