UniProt Accession

 PCFT_HUMAN; Q96NT5; Q1HE20; Q86T92; Q8TEG3; Q96FL0 

Genbank Protein ID

 AK054669; AK074161; DQ496103; BC010691; AL832613 

Genbank Nucleotide ID

 BAB70789.1; BAB84987.1; ABF47092.1; AAH10691.1; CAD89945.1 

Protein Name

 Proton-coupled folate transporter 

Protein Synonyms/Alias

 G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1 

Gene Name

 SLC46A1 

Gene Synonyms/Alias

 HCP1; PCFT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
262	YVAPAPEKSRKHLAL	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. 

Sequence Annotation

 MOD_RES 458 458 Phosphoserine.
 CARBOHYD 58 58 N-linked (GlcNAc...).  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Disease mutation; Folate-binding; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 459 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005542; F:folic acid binding; IEA:UniProtKB-KW.
 GO:0008517; F:folic acid transporter activity; IDA:UniProtKB.
 GO:0015232; F:heme transporter activity; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0046655; P:folic acid metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005829; Sugar_transporter_CS. 

Pfam

 PF07690; MFS_1 

SMART

  

PROSITE

 PS50850; MFS 

PRINTS