| Tag | Content |
|---|
| CPLM ID | CPLM-015667 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Putative Polycomb group protein ASXL2 |
Protein Synonyms/Alias | Additional sex combs-like protein 2 |
Gene Name | ASXL2 |
Gene Synonyms/Alias | ASXH2; KIAA1685 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | QEIEKEKKVEPWKEQ | ubiquitination | [1] | | 110 | EKKVEPWKEQFFESY | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity). Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3. |
Sequence Annotation | ZN_FING 1397 1434 PHD-type; atypical.
MOTIF 174 178 Nuclear localization signal (Potential).
MOTIF 303 307 LXXLL motif 1.
MOTIF 887 891 LXXLL motif 2.
MOD_RES 146 146 Phosphoserine. |
Keyword | Alternative splicing; Chromosomal rearrangement; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1435 AA |
Protein Sequence | MKRTKCADID VETPDSILVN TNLRALINKH TFSVLPGDCQ QRLLLLLPEV DRQVGPDGLM 60
KLNGSALNNE FFTSAAQGWK ERLSEGEFTP EMQVRIRQEI EKEKKVEPWK EQFFESYYGQ 120
SSGLSLEDSK KLTASPSDPK VKKTPAEQPK SMPVSEASLI RIVPVVSQSE CKEEALQMSS 180
PGRKEECESQ GEVQPNFSTS SEPLLSSALN THELSSILPI KCPKDEDLLE QKPVTSAEQE 240
SEKNHLTTAS NYNKSESQES LVTSPSKPKS PGVEKPIVKP TAGAGPQETN MKEPLATLVD 300
QSPESLKRKS SLTQEEAPVS WEKRPRVTEN RQHQQPFQVS PQPFLNRGDR IQVRKVPPLK 360
IPVSRISPMP FHPSQVSPRA RFPVSITSPN RTGARTLADI KAKAQLVKAQ RAAAAAAAAA 420
AAAASVGGTI PGPGPGGGQG PGEGGEGQTA RGGSPGSDRV SETGKGPTLE LAGTGSRGGT 480
RELLPCGPET QPQSETKTTP SQAQPHSVSG AQLQQTPPVP PTPAVSGACT SVPSPAHIEK 540
LDNEKLNPTR ATATVASVSH PQGPSSCRQE KAPSPTGFQL EDISTSQRFM LGFAGRRTSK 600
PAMAGHYLLN ISTYGRGSES FRRTHSVNPE DRFCLSSPTE ALKMGYTDCK NATGESSSSK 660
EDDTDEESTG DEQESVTVKE EPQVSQSAGK GDTSSGPHSR ETLSTSDCLA SKNVKAEIPL 720
NEQTTLSKEN YLFTRGQTFD EKTLARDLIQ AAQKQMAHAV RGKAIRSSPE LFSSTVLPLP 780
ADSPTHQPLL LPPLQTPKLY GSPTQIGPSY RGMINVSTSS DMDHNSAVPG SQVSSNVGDV 840
MSFSVTVTTI PASQAMNPSS HGQTIPVQAF SEENSIEGTP SKCYCRLKAM IMCKGCGAFC 900
HDDCIGPSKL CVSCLVVR 918 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0042975; F:peroxisome proliferator activated receptor binding; IDA:UniProtKB. GO:0045600; P:positive regulation of fat cell differentiation; IDA:UniProtKB. GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; IDA:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |