Tag | Content |
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CPLM ID | CPLM-016318 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Extracellular matrix protein FRAS1 |
Protein Synonyms/Alias | |
Gene Name | FRAS1 |
Gene Synonyms/Alias | KIAA1500 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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3951 | EEYPLNTKVEVPKRH | ubiquitination | [1] | 3989 | PEAAYTFKGAKVKRL | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | |
Sequence Annotation | DOMAIN 27 88 VWFC 1. DOMAIN 93 153 VWFC 2. DOMAIN 157 217 VWFC 3. DOMAIN 219 279 VWFC 4. DOMAIN 283 343 VWFC 5. DOMAIN 347 417 VWFC 6. REPEAT 409 460 FU 1. REPEAT 462 505 FU 2. REPEAT 507 553 FU 3. REPEAT 555 599 FU 4. REPEAT 602 647 FU 5. REPEAT 649 705 FU 6. REPEAT 708 753 FU 7. REPEAT 755 800 FU 8. REPEAT 803 852 FU 9. REPEAT 854 900 FU 10. REPEAT 903 948 FU 11. REPEAT 952 997 FU 12. REPEAT 999 1042 FU 13. REPEAT 1046 1089 FU 14. REPEAT 1090 1201 CSPG 1. REPEAT 1202 1310 CSPG 2. REPEAT 1311 1445 CSPG 3. REPEAT 1446 1574 CSPG 4. REPEAT 1575 1691 CSPG 5. REPEAT 1692 1821 CSPG 6. REPEAT 1822 1939 CSPG 7. REPEAT 1940 2059 CSPG 8. REPEAT 2060 2178 CSPG 9. REPEAT 2179 2293 CSPG 10. REPEAT 2294 2415 CSPG 11. REPEAT 2418 2542 CSPG 12. DOMAIN 2543 2646 Calx-beta 1. DOMAIN 2659 2770 Calx-beta 2. DOMAIN 2784 2890 Calx-beta 3. DOMAIN 2905 3007 Calx-beta 4. DOMAIN 3025 3129 Calx-beta 5. MOD_RES 344 344 Phosphoserine. CARBOHYD 361 361 N-linked (GlcNAc...) (Potential). CARBOHYD 728 728 N-linked (GlcNAc...) (Potential). CARBOHYD 1093 1093 N-linked (GlcNAc...) (Potential). CARBOHYD 1108 1108 N-linked (GlcNAc...) (Potential). CARBOHYD 1504 1504 N-linked (GlcNAc...) (Potential). CARBOHYD 1777 1777 N-linked (GlcNAc...) (Potential). CARBOHYD 1948 1948 N-linked (GlcNAc...) (Potential). CARBOHYD 1978 1978 N-linked (GlcNAc...) (Potential). CARBOHYD 2563 2563 N-linked (GlcNAc...) (Potential). CARBOHYD 2664 2664 N-linked (GlcNAc...) (Potential). CARBOHYD 2682 2682 N-linked (GlcNAc...) (Potential). CARBOHYD 2908 2908 N-linked (GlcNAc...) (Potential). CARBOHYD 2985 2985 N-linked (GlcNAc...) (Potential). CARBOHYD 3070 3070 N-linked (GlcNAc...) (Potential). CARBOHYD 3218 3218 N-linked (GlcNAc...) (Potential). CARBOHYD 3676 3676 N-linked (GlcNAc...) (Potential). CARBOHYD 3875 3875 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Cell membrane; Complete proteome; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4008 AA |
Protein Sequence | MGVLKVWLGL ALALAEFAVL PHHSEGACVY QDSLLADATI WKPDSCQSCR CHGDIVICKP 60 AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK IHEHGTEWAS SPCSVCSCNH 120 GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP VCVGLGKPCS YEGHVFQDGE DWRLSRCAKC 180 LCRNGVAQCF TAQCQPLFCN QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT 240 TCICDRGEVR CHKQACLPLR CGKGQSRARR HGQCCEECVS PAGSCSYDGV VRYQDEMWKG 300 SACEFCMCDH GQVTCQTGEC AKVECARDEE LIHLDGKCCP ECISRNGYCV YEETGEFMSS 360 NASEVKRIPE GEKWEDGPCK VCECRGAQVT CYEPSCPPCP VGTLALEVKG QCCPDCTSVH 420 CHPDCLTCSQ SPDHCDLCQD PTKLLQNGWC VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE 480 CSSCQPPLLM RHGQCVPTCG DGFYQDRHSC AVCHESCAGC WGPTEKHCLA CRDPLHVLRD 540 GGCESSCGKG FYNRQGTCSA CDQSCDSCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD 600 ATGRCKVCHN SCASCSGPTP SHCTACSPPK ALRQGHCLPR CGEGFYSDHG VCKACHSSCL 660 ACMGPAPSHC TGCKKPEEGL QVEQLSDVGI PSGECLAQCR AHFYLESTGI CEACHQSCFR 720 CAGKSPHNCT DCGPSHVLLD GQCLSQCPDG YFHQEGSCTE CHPTCRQCHG PLESDCISCY 780 PHISLTNGNC RTSCREEQFL NLVGYCADCH HLCQHCAADL HNTGSICLRC QNAHYLLLGD 840 HCVPDCPSGY YAERGACKKC HSSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL 900 DDNHVCQPCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STNTCKECDW 960 SCSACSGPLK TDCLQCMDGY VLQDGACVEQ CLSSFYQDSG LCKNCDSYCL QCQGPHECTR 1020 CKGPFLLLEA QCVQECGKGY FADHAKHKCT ACPQGCLQCS HRDRCHLCDH GFFLKSGLCV 1080 YNCVPGFSVH TSNETCSGKI HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF 1140 HVVSTPTNGQ LVLSRNGKEV QLDKAGRFSW KDVNEKKVRF VHSKEKLRKG YLFLKISDQQ 1200 FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQM LDIRDDDNPQ DVVIEIIDPP 1260 LHGQLLQTLQ SPATPIYQFQ LDELSRGLLH YAHDGSDSTS DVAVLQANDG HSFHNILFQV 1320 KTVPQNDRGL QLVANSMVWV PEGGMLQITN RILQAEAPGA SAEEIIYKIT QDYPQFGEVV 1380 LLVNMPADSP ADEGQHLPDG RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFEVSSA 1440 SNAQTRLESH MFNIAILPQT PEAPKVSLEA SLHMTAREDG LTVIQPHSLS FINSEKPSGK 1500 IVYNITLPLH PNQGIIEHRD HPHSPIRYFT QEDINQGKVM YRPPPAAPHL QELMAFSFAG 1560 LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT APRLAVSPGG STSVGLQVVV 1620 RDAETAPKEL FFELRRPPQH GVLLKHTAEF RRPMATGDTF TYEDVEKNAL QYIHDGSSTR 1680 EDSMEISVTD GLTVTMLEVR VEVSLSEDRG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD 1740 DSSPDPEIWI QLNYLPSYGT LLRISGSEVE ELSEVSNFTM EDINNKKIRY SAVFETDGHL 1800 VTDSFYFSVS DMDHNHLDNQ IFTIMITPAE NPPPVIAFAD LITVDEGGRA PLSFHHFFAT 1860 DDDDNLQRDA IIKLSALPKY GCIENTGTGD RFGPETASDL EASFPIQDVL ENYIYYFQSV 1920 HESIEPTHDI FSFYVSDGTS RSEIHSINIT IERKNDEPPR MTLQPLRVQL SSGVVISNSS 1980 LSLQDLDTPD NELIFVLTKK PDHGHVLWRQ TASEPLENGR VLVQGSTFTY QDILAGLVGY 2040 VPSVPGMVVD EFQFSLTDGL HVDTGRMKIY TELPASDTPH LAINQGLQLS AGSVARITEQ 2100 HLKVTDIDSD DHQVMYIMKE DPGAGRLQMM KHGNLEQISI KGPIRSFTQA DISQGHVEYS 2160 HGTGEPGGSF AFKFDVVDGE GNRLIDKSFS ISILEDKSPP VITTNKGLVL DENSVKKITT 2220 LQLSATDQDS GPTELIYRIT RQPQLGHLEH AASPGIQISS FTQADLTSRN VQYVHSSEAE 2280 KHSDAFSFTL SDGVSEVTQT FHITLHPVDD SLPVVQNLGM RVQEGMRKTI TEFELKAVDA 2340 DTEAESVTFT IVQPPRHGTI ERTSNGQHFH LTSTFTMKDI YQNRVSYSHD GSNSLKDRFT 2400 FTVSDGTNPF FIIEEGGKEI MTAAPQPFRV DILPVDDGTP RIVTNLGLQW LEYMDGKATN 2460 LITKKELLTM DPDTEDAQLV YEITTGPKHG FVENKLQPGR AAATFTQEDV NLGLIRYVLH 2520 KEKIREMMDS FQFLVKDSKP NVVSDNVFHI QWSLISFKYT SYNVSEKAGS VSVTVQRTGN 2580 LNQYAIVLCR TEQGTASSSS RVSSQPGQQD YVEYAGQVQF DEREDTKSCT IVINDDDVFE 2640 NVESFTVELS MPAYALLGEF TQAKVIINDT EDEPTLEFDK KIYWVNESAG FLFAPIERKG 2700 DASSIVSAIC YTVPKSAMGS SLYALESGSD FKSRGMSAAS RVIFGPGVTM STCDVMLIDD 2760 SEYEEEEEFE IALADASDNA RIGRVATAKV LISGPNDAST VSLGNTAFTV SEDAGTVKIP 2820 VIRHGTDLST FASVWCATRP SDPASATPGV DYVPSSRKVE FGPGVIEQYC TLTILDDTQY 2880 PVIEGLETFV VFLSSAQGAE LTKPFQAVIA INDTFQDVPS MQFAKDLLLV KEKEGVLHVP 2940 ITRSGDLSYE SSVRCYTQSH SAQVMEDFEE RQNADSSRIT FLKGDKVKNC TVYIHDDSMF 3000 EPEEQFRVYL GLPLGNHWSG ARIGKNNMAT ITISNDEDAP TIEFEEAAYQ VREPAGPDAI 3060 AILNIKVIRR GDQNRTSKVR CSTRDGSAQS GVDYYPKSRV LKFSPGVDHI FFKVEILSNE 3120 DREWHESFSL VLGPDDPVEA VLGDVTTATV TILDQEAAGS LILPAPPIVV TLADYDHVEE 3180 VTKEGVKKSP SPGYPLVCVT PCDPHFPRYA VMKERCSEAG INQTSVQFSW EVAAPTDGNG 3240 ARSPFETITD NTPFTSVNHM VLDSIYFSRR FHVRCVAKAV DKVGHVGTPL RSNIVTIGTD 3300 SAICHTPVVA GTSRGFQAQS FIATLKYLDV KHKEHPNRIH ISVQIPHQDG MLPLISTMPL 3360 HNLHFLLSES IYRHQHVCSN LVTTYDLRGI SEAGFLDDVV YDSTALGPGY DRPFQFDPSV 3420 REPKTIQLYK HLNLKSCVWT FDAYYDMTEL IDVCGGSVTA DFQVRDSAQS FLTVHVPLYV 3480 SYIYVTAPRG WASLEHHTEM EFSFFYDTVL WRTGIQTDSV LSARLQIIRI YIREDGRLVI 3540 EFKTHAKFRG QFVMEHHTLP EVKSFVLTPD HLGGIEFDLQ LLWSAQTFDS PHQLWRATSS 3600 YNRKDYSGEY TIYLIPCTVQ PTQPWVDPGE KPLACTAHAP ERFLIPIAFQ QTNRPVPVVY 3660 SLNTEFQLCN NEKVFLMDPN TSDMSLAEMD YKGAFSKGQI LYGRVLWNPE QNLNSAYKLQ 3720 LEKVYLCTGK DGYVPFFDPT GTIYNEGPQY GCIQPNKHLK HRFLLLDRNQ PEVTDKYFHD 3780 VPFEAHFASE LPDFHVVSNM PGVDGFTLKV DALYKVEAGH QWYLQVIYII GPDTISGPRV 3840 QRSLTAPLRR NRRDLVEPDG QLILDDSLIY DNEGDQVKNG TNMKSLNLEM QELAVAASLS 3900 QTGASIGSAL AAIMLLLLVF LVACFINRKC QKQRKKKPAE DILEEYPLNT KVEVPKRHPD 3960 RVEKNVNRHY CTVRNVNILS EPEAAYTFKG AKVKRLNLEV RVHNNLQDGT EV 4012 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007154; P:cell communication; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |