| Tag | Content |
|---|
| CPLM ID | CPLM-016803 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Beclin 1-associated autophagy-related key regulator |
Protein Synonyms/Alias | Barkor; Autophagy-related protein 14-like protein; Atg14L |
Gene Name | Atg14 |
Gene Synonyms/Alias | D14Ertd436e; Kiaa0831 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 236 | MTSSMVSKLAEARRT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for both basal and inducible autophagy. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Modulates the hepatic lipid metabolism. |
Sequence Annotation | REGION 413 492 BATS.
MOD_RES 29 29 Phosphoserine (By similarity).
MOD_RES 416 416 Phosphoserine (By similarity).
MOD_RES 429 429 Phosphothreonine (By similarity). |
Keyword | Autophagy; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 492 AA |
Protein Sequence | MASPSGKGSW TPEAPGFGPR ALARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ 60
SGDFVYFDGR DRERFIDKKE RLSQLKNKQE EFQKEVLKAM EGKRLTDQLR WKIMSCKMRI 120
EQLKQTICKG NEEMKKNSEG LLKNKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT 180
IDLKSHYERL ARLRRSHILE LTSIIFPIDE VKTSGRDPAD VSSETDSAMT SSMVSKLAEA 240
RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY NWVEEKKTTQ GPDMEHNNPA 300
YTISAALGYA TQLVNIVSHI LDINLPKKLC NSEFCGENLS KQKLTRAVRK LNANILYLCS 360
SQHVNLDQLQ PLHTLRNLMH LVSPRSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDASG 420
DERVSDEETD LGTDWENLPS PRFCDIPSQP VEVSQSQSTQ VSPPIASSSA GGMISSAAAS 480
VTSWFKAYTG HR 492 |
Gene Ontology | GO:0005776; C:autophagic vacuole; IEA:Compara. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0034045; C:pre-autophagosomal structure membrane; IEA:UniProtKB-SubCell. GO:0000045; P:autophagic vacuole assembly; IEA:Compara. GO:0006914; P:autophagy; IMP:UniProtKB. GO:0010508; P:positive regulation of autophagy; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |