| Tag | Content |
|---|
| CPLM ID | CPLM-014704 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Microtubule-associated protein RP/EB family member 1 |
Protein Synonyms/Alias | APC-binding protein EB1; End-binding protein 1; EB1 |
Gene Name | Mapre1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 95 | DKIIPVDKLVKGKFQ | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). |
Sequence Annotation | DOMAIN 14 116 CH.
DOMAIN 185 255 EB1 C-terminal.
REGION 124 268 Interaction with MTUS2/TIP150 (By
REGION 208 268 DCTN1-binding (By similarity).
REGION 220 242 APC-binding (By similarity).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 124 124 Phosphotyrosine (By similarity). |
Keyword | Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Mitosis; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 268 AA |
Protein Sequence | MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK 60
VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD 120
GKEYDPVAAR QGQETAVAPS LVAPALSKPK KPLGSGSAAP QRPIATQRTT AAPKAGPGMV 180
RKNPGMGNGD DEAAELMQQV KVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ 240
RIVDILYATD EGFVIPDEGG PQEEQEEY 268 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005874; C:microtubule; ISS:UniProtKB. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0051010; F:microtubule plus-end binding; IDA:UniProtKB. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0035372; P:protein localization to microtubule; ISS:UniProtKB. |
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