CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020738
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pygopus homolog 1 
Protein Synonyms/Alias
  
Gene Name
 Pygo1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MSAEQDKEPIALKRacetylation[1]
13DKEPIALKRVRGGDSacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Involved in signal transduction through the Wnt pathway (By similarity). 
Sequence Annotation
 ZN_FING 338 396 PHD-type.
 MOTIF 35 41 Nuclear localization signal (Potential).  
Keyword
 3D-structure; Complete proteome; Metal-binding; Nucleus; Reference proteome; Wnt signaling pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MSAEQDKEPI ALKRVRGGDS GLDGLGGPNI QLGSPDKKKR KANTQGSSFP PLSEYAPPPN 60
PNSDHLVAAN PFDDSYNTIS YKPLPSSNPY LGPGYPGFGG YSTFRMPPHV PPRMSSPYCG 120
PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP HDNSNFGNPP YNNVLTQDIN MPGQHFRQGS 180
AENFSQIPPQ NVGQVSNPDL ASNFAPGNNS NFTSPLETNH SFIPPPNAFG QAKAPLPKQD 240
FTQGATKTPN QNSSTHPPHL NMEDPVNQSN VELKNVNRNN VVQENSRSGS AEATNNHANG 300
TQNKPRQPRG AADLCTPDKS RKFSLLPSRH GHSSSDPVYP CGICTNEVND DQDAILCEAS 360
CQKWFHRICT GMTETAYGLL TAEASAVWGC DTCMADKDVQ LMRTREAFGP PAVGGDA 417 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001822; P:kidney development; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0009791; P:post-embryonic development; IGI:MGI.
 GO:0034504; P:protein localization to nucleus; IDA:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IGI:MGI. 
Interpro
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD 
SMART
 SM00249; PHD 
PROSITE
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS