CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008351
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate lyase 
Protein Synonyms/Alias
 ICL; Isocitrase; Isocitratase 
Gene Name
 aceA 
Gene Synonyms/Alias
 STM4184 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
34YSAEEVVKLRGSVNPacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity). 
Sequence Annotation
 ACT_SITE 195 195 By similarity.  
Keyword
 Complete proteome; Cytoplasm; Glyoxylate bypass; Lyase; Phosphoprotein; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MKTRTQQIEE LQKEWTQPRW EGITRPYSAE EVVKLRGSVN PECTLAQLGA AKMWRLLHGE 60
AKKGYINSLG ALTGGQALQQ AKAGIEAIYL SGWQVAADAN LASSMYPDQS LYPANSVPAV 120
VDRINNTFRR ADQIQWASGI EPNDPRYVDY FLPIVADAEA GFGGVLNAFE LMKSMIEAGA 180
AAVHFEDQLA SVKKCGHMGG KVLVPTQEAI QKLVAARLAA DVMGVPTLVI ARTDADAADL 240
ITSDCDPYDS GFITGERTSE GFYRTHAGIE QAISRGLAYA PYADLVWCET STPDLELARR 300
FADAIHAKYP GKLLAYNCSP SFNWQKNLDD KTIASFQQQL SDMGYKYQFI TLAGIHSMWF 360
NMFDLAHAYA QGEGMKHYVE KVQQPEFAAA KDGYTFVSHQ QEVGTGYFDK VTTIIQGGAS 420
SVTALTGSTE EAQF 434 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004451; F:isocitrate lyase activity; IEA:EC.
 GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-UniPathway.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR006254; Isocitrate_lyase.
 IPR000918; Isocitrate_lyase/Pmutase.
 IPR018523; Isocitrate_lyase_ph_CS.
 IPR015813; Pyrv/PenolPyrv_Kinase-like_dom. 
Pfam
 PF00463; ICL 
SMART
  
PROSITE
 PS00161; ISOCITRATE_LYASE 
PRINTS