| Tag | Content |
|---|
| CPLM ID | CPLM-022838 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | cAMP-regulated phosphoprotein 21 |
Protein Synonyms/Alias | ARPP-21; Thymocyte cAMP-regulated phosphoprotein |
Gene Name | ARPP21 |
Gene Synonyms/Alias | TARPP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 187 | DNNNHYKKFPQMSSY | ubiquitination | [1] | | 217 | HNVDQTGKSVIINKT | ubiquitination | [1] | | 223 | GKSVIINKTSSTRIP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity). |
Sequence Annotation | DOMAIN 164 227 R3H.
DOMAIN 228 300 SUZ.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 33 33 Phosphoserine.
MOD_RES 56 56 Phosphoserine (By similarity).
MOD_RES 280 280 Phosphoserine (By similarity).
MOD_RES 383 383 Phosphoserine.
MOD_RES 562 562 Phosphoserine.
MOD_RES 655 655 Omega-N-methylated arginine (Probable). |
Keyword | Acetylation; Alternative splicing; Calmodulin-binding; Coiled coil; Complete proteome; Cytoplasm; Methylation; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 812 AA |
Protein Sequence | MSEQGDLNQA IAEEGGTEQE TATPENGIVK SESLDEEEKL ELQRRLEAQN QERRKSKSGA 60
GKGKLTRSLA VCEESSARPG GESLQDQESI HLQLSSFSSL QEEDKSRKDD SEREKEKDKN 120
KDKTSEKPKI RMLSKDCSQE YTDSTGIDLH EFLINTLKNN SRDRMILLKM EQEIIDFIAD 180
NNNHYKKFPQ MSSYQRMLVH RVAAYFGLDH NVDQTGKSVI INKTSSTRIP EQRFCEHLKD 240
EKGEESQKRF ILKRDNSSID KEDNQSVCSQ ESLFVENSRL LEDSNICNET YKKRQLFRGN 300
RDGSGRTSGS RQSSSENELK WSDHQRAWSS TDSDSSNRNL KPAMTKTASF GGITVLTRGD 360
STSSTRSTGK LSKAGSESSS SAGSSGSLSR THPPLQSTPL VSGVAAGSPG CVPYPENGIG 420
GQVAPSSTSY ILLPLEAATG IPPGSILLNP HTGQPFVNPD GTPAIYNPPT SQQPLRSAMV 480
GQSQQQPPQQ QPSPQPQQQV QPPQPQMAGP LVTQSVQGLQ ASSQSVQYPA VSFPPQHLLP 540
VSPTQHFPMR DDVATQFGQM TLSRQSSGET PEPPSGPVYP SSLMPQPAQQ PSYVIASTGQ 600
QLPTGGFSGS GPPISQQVLQ PPPSPQGFVQ QPPPAQMPVY YYPSGQYPTS TTQQYRPMAP 660
VQYNAQRSQQ MPQAAQQAGY QPVLSGQQGF QGLIGVQQPP QSQNVINNQQ GTPVQSVMVS 720
YPTMSSYQVP MTQGSQGLPQ QSYQQPIMLP NQAGQGSLPA TGMPVYCNVT PPTPQNNLRL 780
IGPHCPSSTV PVMSASCRTN CASMSNAGWQ VKF 813 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0034605; P:cellular response to heat; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |