CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004417
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Threonine synthase 
Protein Synonyms/Alias
 TS 
Gene Name
 THR4 
Gene Synonyms/Alias
 YCR053W; YCR53W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
81EIPDADLKDLIKRSYacetylation[1]
228VKAIFGDKEFNSKHNacetylation[1]
233GDKEFNSKHNVGAVNacetylation[1]
313DILDRFLKSGLYERSacetylation[1]
380NGKFQVDKSIIEGASacetylation[1]
388SIIEGASKDFTSERVacetylation[1]
440LIAKDNDKSIQYISLacetylation[1]
502RADVELVKNAIEEELacetylation[1]
502RADVELVKNAIEEELubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity). 
Sequence Annotation
 MOD_RES 124 124 N6-(pyridoxal phosphate)lysine (By
 MOD_RES 467 467 Phosphoserine.  
Keyword
 3D-structure; Amino-acid biosynthesis; Complete proteome; Lyase; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Threonine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 514 AA 
Protein Sequence
MPNASQVYRS TRSSSPKTIS FEEAIIQGLA TDGGLFIPPT IPQVDQATLF NDWSKLSFQD 60
LAFAIMRLYI AQEEIPDADL KDLIKRSYST FRSDEVTPLV QNVTGDKENL HILELFHGPT 120
YAFKDVALQF VGNLFEYFLQ RTNANLPEGE KKQITVVGAT SGDTGSAAIY GLRGKKDVSV 180
FILYPTGRIS PIQEEQMTTV PDENVQTLSV TGTFDNCQDI VKAIFGDKEF NSKHNVGAVN 240
SINWARILAQ MTYYFYSFFQ ATNGKDSKKV KFVVPSGNFG DILAGYFAKK MGLPIEKLAI 300
ATNENDILDR FLKSGLYERS DKVAATLSPA MDILISSNFE RLLWYLAREY LANGDDLKAG 360
EIVNNWFQEL KTNGKFQVDK SIIEGASKDF TSERVSNEET SETIKKIYES SVNPKHYILD 420
PHTAVGVCAT ERLIAKDNDK SIQYISLSTA HPAKFADAVN NALSGFSNYS FEKDVLPEEL 480
KKLSTLKKKL KFIERADVEL VKNAIEEELA KMKL 514 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0004795; F:threonine synthase activity; IMP:SGD.
 GO:0009088; P:threonine biosynthetic process; IMP:SGD. 
Interpro
 IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
 IPR004450; Thr_synthase_like.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 
Pfam
 PF00291; PALP 
SMART
  
PROSITE
 PS00165; DEHYDRATASE_SER_THR 
PRINTS