CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030284
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sprouty homolog 2 (Drosophila) 
Protein Synonyms/Alias
  
Gene Name
 Spry2 
Gene Synonyms/Alias
 mCG_121239 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
164ELKPGDVKPLSKDDLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 315 AA 
Protein Sequence
MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 60
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH SSRAPLSRSI STVSSGSRSS 120
TRTSTSSSSS EQRLLGPSFS HGPAAADGII RVQPKSELKP GDVKPLSKDD LGLHAYRCED 180
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 240
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 300
CKVPTVPPRN FEKPT 315 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IMP:MGI.
 GO:0045165; P:cell fate commitment; IMP:MGI.
 GO:0042472; P:inner ear morphogenesis; IMP:MGI.
 GO:0060437; P:lung growth; IDA:MGI.
 GO:0060425; P:lung morphogenesis; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:MGI.
 GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IDA:MGI.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:MGI.
 GO:0051387; P:negative regulation of neurotrophin TRK receptor signaling pathway; IDA:MGI.
 GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Compara.
 GO:0034261; P:negative regulation of Ras GTPase activity; IDA:MGI.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:MGI.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0051897; P:positive regulation of protein kinase B signaling cascade; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IMP:MGI. 
Interpro
 IPR007875; Sprouty. 
Pfam
 PF05210; Sprouty 
SMART
  
PROSITE
 PS51227; SPR 
PRINTS