CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037038
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 39S ribosomal protein L22, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MRPL22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92DKMWYLAKLIRGMSIubiquitination[1]
111AQLEFNDKKGAKIIKubiquitination[1, 2]
112QLEFNDKKGAKIIKEubiquitination[1]
118KKGAKIIKEVLLEAQubiquitination[1]
190PPPPEPPKTAVAHAKubiquitination[1]
197KTAVAHAKEYIQQLRubiquitination[1, 2, 3, 4, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 212 AA 
Protein Sequence
MAAAVLGQLG ALWIHNLRSR GKLALGLLSF HSVLPQSYIH TSASLDISRK WEKKNKIVYP 60
PQLPGEPRRP AEIYHCRRQI KYSKDKMWYL AKLIRGMSID QALAQLEFND KKGAKIIKEV 120
LLEAQDMAVR DHNVEFRSNL YIAESTSGRG QCLKRIRYHG RGRFGIMEKV YCHYFVKLVE 180
GPPPPPEPPK TAVAHAKEYI QQLRSRTIVH TL 212 
Gene Ontology
 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR001063; Ribosomal_L22.
 IPR005727; Ribosomal_L22_bac/chlpt-type. 
Pfam
 PF00237; Ribosomal_L22 
SMART
  
PROSITE
  
PRINTS