CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform 
Protein Synonyms/Alias
 MLC-2; MLC-2v 
Gene Name
 Myl2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
62ALGRVNVKNEEIDEMacetylation[1]
91TMFGEKLKGADPEETacetylation[1]
115PEGKGSLKADYVREMacetylation[1]
165IITHGEEKD******acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
 DOMAIN 24 59 EF-hand 1.
 DOMAIN 94 129 EF-hand 2.
 DOMAIN 130 165 EF-hand 3.  
Keyword
 Calcium; Complete proteome; Cytoplasm; Metal-binding; Methylation; Motor protein; Muscle protein; Myosin; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 166 AA 
Protein Sequence
MSPKKAKKRL EGGSSNVFSM FEQTQIQEFK EAFTIMDQNR DGFIDKNDLR DTFAALGRVN 60
VKNEEIDEMI KEAPGPINFT VFLTMFGEKL KGADPEETIL NAFKVFDPEG KGSLKADYVR 120
EMLTTQAERF SKEEIDQMFA AFPPDVTGNL DYKNLVHIIT HGEEKD 166 
Gene Ontology
 GO:0030016; C:myofibril; IDA:RGD.
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0060048; P:cardiac muscle contraction; IDA:RGD. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF00036; efhand 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS