CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039609
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HLA class I histocompatibility antigen, Cw-14 alpha chain 
Protein Synonyms/Alias
  
Gene Name
 HLA-C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
247LQRAEPPKTHVTHHPubiquitination[1]
304AGDGTFQKWAAVVVPubiquitination[1]
378RRKSSGGKGGSCSQAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in the presentation of foreign antigens to the immune system (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Immunity; Membrane; MHC I; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MRVMAPRALL LLLSGGLALT ETWACECGVG REAASAERSE GPPGEPRREV GRAGLSPSSP 60
PGSHSMRYFD TAVSRPGRGE PRFISVGYVD DTQFVRFDSD AASPRGEPRA PWVEQEGPEY 120
WDRETQKYKR QAQADRVSLR NLRGYYNQSE DGSHTLQRMS GCDLGPDGRL LRGYDQSAYD 180
GKDYIALNED LRSWTAADTA AQITQRKLEA ARAAEQLRAY LEGTCVEWLR RYLENGKETL 240
QRAEPPKTHV THHPLSDHEA TLRCWALGFY PAEITLTWQR DGEDQTQDTE LVETRPAGDG 300
TFQKWAAVVV PSGQEQRYTC HMQHEGLQEP LTLSWEPSSQ PTIPIMGIVA GLAVLVVLAV 360
LGAVVTAMMC RRKSSGGKGG SCSQAACSNS AQGSDESLIT CKA 403 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; IEA:InterPro. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 
Pfam
 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 
SMART
 SM00407; IGc1 
PROSITE
 PS50835; IG_LIKE 
PRINTS
 PR01638; MHCCLASSI.