CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013638
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methylthioribose-1-phosphate isomerase 
Protein Synonyms/Alias
 M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein 
Gene Name
 Mri1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
259ANGDTANKIGTYQLAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity). 
Sequence Annotation
 ACT_SITE 248 248 Proton donor (By similarity).  
Keyword
 Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase; Methionine biosynthesis; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 369 AA 
Protein Sequence
MRLEAIRYSP GSLQILDQLQ LPEHCHYETL SSVQQAREAI RAMKVRGAPA IALVGCLSLA 60
VELQAGAGGP GLAALVAFVR DQLSLLVAAR PTAVNMARAA RDLTHMAARE AELEGATEET 120
VRERVIRFAE DMLEKDLKDN RSIGDLGARH LLEQTNPRGG KVTVLTHCNT GALATAGYGT 180
ALGVIRSLHE MGRLEHTFCT ETRPYNQGAR LTAFELVYEK IPATLITDSM AAAAMVHQGV 240
SAVVVGADRV VANGDTANKI GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIVIEER 300
PSQELTDLNG VRIAAQGIRV WNPAFDVTPH ELITGGIITE LGVFAPEELR AALSATIFSE 360
GQTLDSPQM 369 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IBA:RefGenome.
 GO:0019284; P:L-methionine biosynthetic process from S-adenosylmethionine; IEA:HAMAP.
 GO:0019509; P:L-methionine salvage from methylthioadenosine; IBA:RefGenome. 
Interpro
 IPR000649; IF-2B-related.
 IPR005251; IF-2BI_MTNA.
 IPR011559; Initiation_fac_2B_a/b/d.
 IPR027363; M1Pi_N. 
Pfam
 PF01008; IF-2B 
SMART
  
PROSITE
  
PRINTS