UniProt Accession

 DC1L1_MOUSE; Q8R1Q8 

Genbank Protein ID

 BC023347 

Genbank Nucleotide ID

 AAH23347.1 

Protein Name

 Cytoplasmic dynein 1 light intermediate chain 1 

Protein Synonyms/Alias

 Dynein light chain A; DLC-A; Dynein light intermediate chain 1, cytosolic 

Gene Name

 Dync1li1 

Gene Synonyms/Alias

 Dncli1; Dnclic1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
303	VYKYIVQKLYGFPYK	acetylation	[1]
385	KLQSLLAKQPPTAAG	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity). 

Sequence Annotation

 NP_BIND 74 81 ATP (Potential).
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 213 213 Phosphothreonine (By similarity).
 MOD_RES 398 398 Phosphoserine (By similarity).
 MOD_RES 405 405 Phosphoserine.
 MOD_RES 408 408 Phosphothreonine (By similarity).
 MOD_RES 419 419 Phosphoserine (By similarity).
 MOD_RES 421 421 Phosphoserine (By similarity).
 MOD_RES 486 486 Phosphoserine (By similarity).
 MOD_RES 510 510 Phosphoserine.
 MOD_RES 512 512 Phosphothreonine (By similarity).
 MOD_RES 513 513 Phosphothreonine.
 MOD_RES 515 515 Phosphothreonine.
 MOD_RES 516 516 Phosphoserine.
 MOD_RES 518 518 Phosphothreonine.  

Keyword

 ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Kinetochore; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 523 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
 GO:0000776; C:kinetochore; ISS:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; ISS:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007018; P:microtubule-based movement; ISS:MGI.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR008467; Dynein1_light_intermed_chain.
 IPR022780; Dynein_light_int_chain.
 IPR027417; P-loop_NTPase. 

Pfam

 PF05783; DLIC 

SMART

  

PROSITE

  

PRINTS