UniProt Accession

 SRF_HUMAN; P11831; Q5T648 

Genbank Protein ID

 J03161; AL133375; AL355385; AL355385; AL133375; CH471081; BC048211; BC052572 

Genbank Nucleotide ID

 AAA36647.1; CAI20207.1; CAI20207.1; CAI13785.1; CAI13785.1; EAX04161.1; AAH48211.1; AAH52572.1 

Protein Name

 Serum response factor 

Protein Synonyms/Alias

 SRF 

Gene Name

 SRF 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
147	TRGRVKIKMEFIDNK	sumoylation	[1]

Reference

 [1] Serum response factor is modulated by the SUMO-1 conjugation system.
 Matsuzaki K, Minami T, Tojo M, Honda Y, Uchimura Y, Saitoh H, Yasuda H, Nagahiro S, Saya H, Nakao M.
 Biochem Biophys Res Commun. 2003 Jun 20;306(1):32-8. [PMID: 12788062] 

Functional Description

 SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation. 

Sequence Annotation

 DOMAIN 141 201 MADS-box.
 DNA_BIND 133 222
 REGION 168 222 Involved in dimerization.
 MOD_RES 77 77 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 103 103 Phosphoserine.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 253 253 Phosphoserine.
 MOD_RES 435 435 Phosphoserine; by dsDNA kinase.
 MOD_RES 446 446 Phosphoserine; by dsDNA kinase.
 CARBOHYD 277 277 O-linked (GlcNAc).
 CARBOHYD 307 307 O-linked (GlcNAc) (Probable).
 CARBOHYD 309 309 O-linked (GlcNAc) (Probable).
 CARBOHYD 316 316 O-linked (GlcNAc).
 CARBOHYD 383 383 O-linked (GlcNAc) (Probable).  

Keyword

 3D-structure; Activator; Complete proteome; Developmental protein; Direct protein sequencing; DNA-binding; Glycoprotein; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 508 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:BHF-UCL.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0031490; F:chromatin DNA binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IEA:Compara.
 GO:0010736; F:serum response element binding; IDA:BHF-UCL.
 GO:0060055; P:angiogenesis involved in wound healing; TAS:BHF-UCL.
 GO:0008306; P:associative learning; IEA:Compara.
 GO:0055003; P:cardiac myofibril assembly; IEA:Compara.
 GO:0060947; P:cardiac vascular smooth muscle cell differentiation; IEA:Compara.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0090398; P:cellular senescence; IMP:BHF-UCL.
 GO:0030038; P:contractile actin filament bundle assembly; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0035912; P:dorsal aorta morphogenesis; IEA:Compara.
 GO:0090136; P:epithelial cell-cell adhesion; IEA:Compara.
 GO:0010669; P:epithelial structure maintenance; IEA:Compara.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0061029; P:eyelid development in camera-type eye; IEA:Compara.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0060347; P:heart trabecula formation; IEA:Compara.
 GO:0060218; P:hematopoietic stem cell differentiation; IEA:Compara.
 GO:0021766; P:hippocampus development; IEA:Compara.
 GO:0060292; P:long term synaptic depression; IEA:Compara.
 GO:0035855; P:megakaryocyte development; IEA:Compara.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0002011; P:morphogenesis of an epithelial sheet; IEA:Compara.
 GO:0042789; P:mRNA transcription from RNA polymerase II promoter; ISS:BHF-UCL.
 GO:0046716; P:muscle cell homeostasis; ISS:BHF-UCL.
 GO:1900222; P:negative regulation of beta-amyloid clearance; IMP:BHF-UCL.
 GO:0048666; P:neuron development; TAS:BHF-UCL.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0001569; P:patterning of blood vessels; IEA:Compara.
 GO:0030168; P:platelet activation; IEA:Compara.
 GO:0030220; P:platelet formation; IEA:Compara.
 GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
 GO:0051491; P:positive regulation of filopodium assembly; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045987; P:positive regulation of smooth muscle contraction; IDA:BHF-UCL.
 GO:0003257; P:positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; IGI:BHF-UCL.
 GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0010735; P:positive regulation of transcription via serum response element binding; IDA:BHF-UCL.
 GO:0045059; P:positive thymic T cell selection; IEA:Compara.
 GO:0090009; P:primitive streak formation; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0051150; P:regulation of smooth muscle cell differentiation; TAS:BHF-UCL.
 GO:0033561; P:regulation of water loss via skin; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IMP:BHF-UCL.
 GO:0009725; P:response to hormone stimulus; IDA:BHF-UCL.
 GO:0001666; P:response to hypoxia; IEP:BHF-UCL.
 GO:0009636; P:response to toxic substance; TAS:BHF-UCL.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0043589; P:skin morphogenesis; IEA:Compara.
 GO:0043149; P:stress fiber assembly; IEA:Compara.
 GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IDA:MGI. 

Interpro

 IPR002100; TF_MADSbox. 

Pfam

 PF00319; SRF-TF 

SMART

 SM00432; MADS 

PROSITE

 PS00350; MADS_BOX_1
 PS50066; MADS_BOX_2 

PRINTS

 PR00404; MADSDOMAIN.