CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nonsense-mediated mRNA decay protein 3 
Protein Synonyms/Alias
 Up-frameshift suppressor 3 
Gene Name
 UPF3 
Gene Synonyms/Alias
 SUA6; YGR072W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
331VIIEEAGKEVLKQRKubiquitination[1]
Reference
 [1] Systematic approach for validating the ubiquitinated proteome.
 Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
 Anal Chem. 2008 Jun 1;80(11):4161-9. [PMID: 18433149] 
Functional Description
 Involved in nonsense-mediated decay of mRNAs containing premature stop codons. 
Sequence Annotation
 MOTIF 15 31 Nuclear localization signal (Potential).
 MOTIF 58 75 Nuclear localization signal (Potential).
 MOTIF 284 300 Nuclear localization signal (Potential).  
Keyword
 Complete proteome; Nonsense-mediated mRNA decay; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 387 AA 
Protein Sequence
MSNVAGELKN SEGKKKGRGN RYHNKNRGKS KNETVDPKKN ENKVNNATNA THNNSKGRRN 60
NKKRNREYYN YKRKARLGKS TENEGFKLVI RLLPPNLTAD EFFAILRDNN NDDGDKQDIQ 120
GKLKYSDWCF FEGHYSSKVF KNSTYSRCNF LFDNLSDLEK CANFIKTCKF IDNKDNITIP 180
DMKLSPYVKK FTQTSKKDAA LVGTIEEDEI FKTFMNSMKQ LNENDEYSFQ DFSVLKSLEK 240
EFSKSIELEN KIAERTERVL TELVGTGDKV KNKNKKKKNK NAKKKFKEEE ASAKIPKKKR 300
NRGKKKRENR EKSTISKTKN SNVVIIEEAG KEVLKQRKKK MLLQEKLKIS NSSQPQSSSA 360
QTQPSFQPKE NLFVPRVKIL HRDDTKK 387 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0005844; C:polysome; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IGI:SGD.
 GO:0016567; P:protein ubiquitination; IMP:SGD. 
Interpro
 IPR005120; Nonsense_mediated_decay_UPF3.
 IPR012677; Nucleotide-bd_a/b_plait. 
Pfam
 PF03467; Smg4_UPF3 
SMART
  
PROSITE
  
PRINTS