UniProt Accession

 MED19_DROME; Q9VVL6 

Genbank Protein ID

 AE014296; AY069647 

Genbank Nucleotide ID

 AAF49295.1; AAL39792.1 

Protein Name

 Mediator of RNA polymerase II transcription subunit 19 

Protein Synonyms/Alias

 Mediator complex subunit 19 

Gene Name

 MED19 

Gene Synonyms/Alias

 CG5546 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
42	KTTISLGKTPTIIHT	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 

Sequence Annotation

  

Keyword

 Activator; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016592; C:mediator complex; ISS:UniProtKB.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; ISS:UniProtKB. 

Interpro

 IPR019403; Mediator_Med19_met. 

Pfam

 PF10278; Med19 

SMART

  

PROSITE

  

PRINTS