UniProt Accession

 CHM2A_MOUSE; Q9DB34 

Genbank Protein ID

 AK005267; BC012230 

Genbank Nucleotide ID

 BAB23919.1; AAH12230.1 

Protein Name

 Charged multivesicular body protein 2a 

Protein Synonyms/Alias

 Chromatin-modifying protein 2a; CHMP2a; Vacuolar protein sorting-associated protein 2; mVps2 

Gene Name

 Chmp2a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	ADIKKMAKQGQMDAV	ubiquitination	[1]
89	NIQAVSLKIQTLKSN	ubiquitination	[1]
94	SLKIQTLKSNNSMAQ	ubiquitination	[1]
104	NSMAQAMKGVTKAMG	ubiquitination	[1]
108	QAMKGVTKAMGTMNR	ubiquitination	[1]
124	LKLPQIQKIMMEFER	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). 

Sequence Annotation

 REGION 56 222 Interaction with VPS4B (By similarity).
 REGION 217 222 Interaction with VTA1 (By similarity).
 MOTIF 210 220 MIT-interacting motif.
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR005024; Snf7. 

Pfam

 PF03357; Snf7 

SMART

  

PROSITE

  

PRINTS