CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041974
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphodiesterase 5A, cGMP-specific, isoform CRA_a 
Protein Synonyms/Alias
 cGMP-specific 3',5'-cyclic phosphodiesterase 
Gene Name
 PDE5A 
Gene Synonyms/Alias
 hCG_38154 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
662EEYKTTLKIIKQAILubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 823 AA 
Protein Sequence
MVNAWFAERV HTIPVCKEGI RGHTESCSCP LQQSPRADNS APGTPTRKIS ASEFDRPLRP 60
IVVKDSEGTV SFLSDSEKKE QMPLTPPRFD HDEGDQCSRL LELVKDISSH LDVTALCHKI 120
FLHIHGLISA DRYSLFLVCE DSSNDKFLIS RLFDVAEGST LEEVSNNCIR LEWNKGIVGH 180
VAALGEPLNI KDAYEDPRFN AEVDQITGYK TQSILCMPIK NHREEVVGVA QAINKKSGNG 240
GTFTEKDEKD FAAYLAFCGI VLHNAQLYET SLLENKRNQV LLDLASLIFE EQQSLEVILK 300
KIAATIISFM QVQKCTIFIV DEDCSDSFSS VFHMECEELE KSSDTLTREH DANKINYMYA 360
QYVKNTMEPL NIPDVSKDKR FPWTTENTGN VNQQCIRSLL CTPIKNGKKN KVIGVCQLVN 420
KMEENTGKVK PFNRNDEQFL EAFVIFCGLG IQNTQMYEAV ERAMAKQMVT LEVLSYHASA 480
AEEETRELQS LAAAVVPSAQ TLKITDFSFS DFELSDLETA LCTIRMFTDL NLVQNFQMKH 540
EVLCRWILSV KKNYRKNVAY HNWRHAFNTA QCMFAALKAG KIQNKLTDLE ILALLIAALS 600
HDLDHRGVNN SYIQRSEHPL AQLYCHSIME HHHFDQCLMI LNSPGNQILS GLSIEEYKTT 660
LKIIKQAILA TDLALYIKRR GEFFELIRKN QFNLEDPHQK ELFLAMLMTA CDLSAITKPW 720
PIQQRIAELV ATEFFDQGDR ERKELNIEPT DLMNREKKNK IPSMQVGFID AICLQLYEAL 780
THVSEDCFPL LDGCRKNRQK WQALAEQQEK MLINGESGQA KRN 823 
Gene Ontology
 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0030553; F:cGMP binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046068; P:cGMP metabolic process; IEA:Compara.
 GO:0055118; P:negative regulation of cardiac muscle contraction; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0060282; P:positive regulation of oocyte development; IEA:Compara.
 GO:0055119; P:relaxation of cardiac muscle; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.