| Tag | Content |
|---|
| CPLM ID | CPLM-022656 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Beta-adducin |
Protein Synonyms/Alias | Add97; Erythrocyte adducin subunit beta |
Gene Name | Add2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 77 | LIQEQMKKGNNSSNI | ubiquitination | [1] | | 527 | LASVIAEKSRSPSTE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). |
Sequence Annotation | REGION 425 444 Interaction with calmodulin (Potential).
REGION 703 720 Interaction with calmodulin (Potential).
MOD_RES 2 2 N-acetylserine.
MOD_RES 55 55 Phosphothreonine (By similarity).
MOD_RES 530 530 Phosphoserine (By similarity).
MOD_RES 532 532 Phosphoserine.
MOD_RES 535 535 Phosphoserine.
MOD_RES 561 561 Phosphothreonine.
MOD_RES 594 594 Phosphoserine.
MOD_RES 598 598 Phosphoserine (By similarity).
MOD_RES 602 602 Phosphoserine.
MOD_RES 606 606 Phosphoserine (By similarity).
MOD_RES 612 612 Phosphothreonine (By similarity).
MOD_RES 614 614 Phosphoserine (By similarity).
MOD_RES 618 618 Phosphoserine (By similarity).
MOD_RES 687 687 Phosphothreonine.
MOD_RES 692 692 Phosphoserine (By similarity).
MOD_RES 696 696 Phosphoserine (By similarity).
MOD_RES 702 702 Phosphoserine (By similarity).
MOD_RES 712 712 Phosphoserine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; Calmodulin-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 725 AA |
Protein Sequence | MSEDTVPEAA SPPPSQGQHY FDRFSEDDPE YLRLRNRAAD LRQDFNLMEQ KKRVTMILQS 60
PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA VFPASSMNFS MMTPINDLHT 120
ADSLNLAKGE RLMRCKISSV YRLLDLYGWA QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV 180
TASSLIKVNI LGEVVEKGSS CFPVDTTGFS LHSAIYAARP DVRCAIHLHT PATAAVSAMK 240
CGLLPVSHNA LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GMVALGDTVE 300
EAFYKVFHLQ AACEVQVSAL SSAGGTENLI LLEQEKHRPH EVGSVQWAGS TFGPMQKSRL 360
GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI PATVTAFVFE EDGVPVPALR 420
QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ RNMGSPRPKT TWMKADEVEK SSSGMPIRIE 480
NPNQFVPLYT DPQEVLDMRN KIREQNRQDI KSAGPQSQLL ASVIAEKSRS PSTESQLMSK 540
GDADTKDESE ETVPNPFSQL TDQELEEYKK EVERKKLEQE QEGEKDIATE KPGSPVKSTP 600
ASPVQSPSKA GTKSPAVSPS KTSEDTKKTE VSEANTEPEP VKPEGLVVNG KEEEPSVEEA 660
LSKGLGQMTT NADTDGDSYK DKTESVTSGP LSPEGSPSKS PSKKKKKFRT PSFLKKSKKK 720
EKVES 725 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB. GO:0008290; C:F-actin capping protein complex; IEA:Compara. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:InterPro. GO:0005198; F:structural molecule activity; IDA:MGI. GO:0051017; P:actin filament bundle assembly; IEA:Compara. GO:0051016; P:barbed-end actin filament capping; IEA:Compara. GO:0030097; P:hemopoiesis; IMP:MGI. GO:0032092; P:positive regulation of protein binding; IEA:Compara. GO:0006461; P:protein complex assembly; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |