| Tag | Content |
|---|
| CPLM ID | CPLM-019189 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arylsulfatase G |
Protein Synonyms/Alias | ASG |
Gene Name | ARSG |
Gene Synonyms/Alias | KIAA1001; UNQ839/PRO1777 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 226 | LAQKYAEKATQFIQR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbelliferyl sulfate. |
Sequence Annotation | ACT_SITE 139 139 By similarity.
METAL 44 44 Calcium (By similarity).
METAL 45 45 Calcium (By similarity).
METAL 84 84 Calcium; via 3-oxoalanine (By
METAL 302 302 Calcium (By similarity).
METAL 303 303 Calcium (By similarity).
BINDING 137 137 Substrate (By similarity).
BINDING 162 162 Substrate (By similarity).
BINDING 251 251 Substrate (By similarity).
MOD_RES 84 84 3-oxoalanine (Cys).
CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
CARBOHYD 215 215 N-linked (GlcNAc...) (Potential).
CARBOHYD 356 356 N-linked (GlcNAc...) (Potential).
CARBOHYD 497 497 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Complete proteome; Glycoprotein; Hydrolase; Lysosome; Metal-binding; Polymorphism; Reference proteome; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 525 AA |
Protein Sequence | MGWLFLKVLL AGVSFSGFLY PLVDFCISGK TRGQKPNFVI ILADDMGWGD LGANWAETKD 60
TANLDKMASE GMRFVDFHAA ASTCSPSRAS LLTGRLGLRN GVTRNFAVTS VGGLPLNETT 120
LAEVLQQAGY VTGIIGKWHL GHHGSYHPNF RGFDYYFGIP YSHDMGCTDT PGYNHPPCPA 180
CPQGDGPSRN LQRDCYTDVA LPLYENLNIV EQPVNLSSLA QKYAEKATQF IQRASTSGRP 240
FLLYVALAHM HVPLPVTQLP AAPRGRSLYG AGLWEMDSLV GQIKDKVDHT VKENTFLWFT 300
GDNGPWAQKC ELAGSVGPFT GFWQTRQGGS PAKQTTWEGG HRVPALAYWP GRVPVNVTST 360
ALLSVLDIFP TVVALAQASL PQGRRFDGVD VSEVLFGRSQ PGHRVLFHPN SGAAGEFGAL 420
QTVRLERYKA FYITGGARAC DGSTGPELQH KFPLIFNLED DTAEAVPLER GGAEYQAVLP 480
EVRKVLADVL QDIANDNISS ADYTQDPSVT PCCNPYQIAC RCQAA 525 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome. GO:0005615; C:extracellular space; IDA:UniProtKB. GO:0005764; C:lysosome; IDA:UniProtKB. GO:0004065; F:arylsulfatase activity; IDA:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome. GO:0043687; P:post-translational protein modification; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. GO:0006790; P:sulfur compound metabolic process; IDA:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |