CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010879
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/calcium exchanger 1 
Protein Synonyms/Alias
 Na(+)/Ca(2+)-exchange protein 1 
Gene Name
 Slc8a1 
Gene Synonyms/Alias
 Ncx1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
647LTEEYDDKQPLTSKEubiquitination[1]
653DKQPLTSKEEEERRIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. 
Sequence Annotation
 REPEAT 138 178 Alpha-1.
 DOMAIN 393 493 Calx-beta 1.
 DOMAIN 524 624 Calx-beta 2.
 REPEAT 840 876 Alpha-2.
 REGION 251 270 Calmodulin-binding (By similarity).
 METAL 417 417 Calcium 3 (By similarity).
 METAL 453 453 Calcium 1 (By similarity).
 METAL 453 453 Calcium 2 (By similarity).
 METAL 478 478 Calcium 4 (By similarity).
 METAL 479 479 Calcium 3 (By similarity).
 METAL 479 479 Calcium 4; via carbonyl oxygen (By
 METAL 481 481 Calcium 3; via carbonyl oxygen (By
 METAL 483 483 Calcium 1 (By similarity).
 METAL 483 483 Calcium 2 (By similarity).
 METAL 483 483 Calcium 3 (By similarity).
 METAL 486 486 Calcium 1 (By similarity).
 METAL 530 530 Calcium 3 (By similarity).
 METAL 531 531 Calcium 4 (By similarity).
 METAL 532 532 Calcium 3 (By similarity).
 METAL 532 532 Calcium 4 (By similarity).
 METAL 548 548 Calcium 6 (By similarity).
 METAL 584 584 Calcium 5 (By similarity).
 METAL 610 610 Calcium 5 (By similarity).
 METAL 610 610 Calcium 6 (By similarity).
 METAL 612 612 Calcium 6 (By similarity).
 METAL 681 681 Calcium 6 (By similarity).
 CARBOHYD 41 41 N-linked (GlcNAc...) (Potential).
 CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Antiport; Calcium; Calcium transport; Calmodulin-binding; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Metal-binding; Reference proteome; Repeat; Signal; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 971 AA 
Protein Sequence
MLRLSLPPNV SMGFRLVTLV ALLFTHVDHI TADTEAETGG NETTECTGSY YCKKGVILPI 60
WEPQDPSFGD KIARATVYFV AMVYMFLGVS IIADRFMSSI EVITSQEKEI TIKKPNGETT 120
KTTVRIWNET VSNLTLMALG SSAPEILLSV IEVCGHNFTA GDLGPSTIVG SAAFNMFIII 180
ALCVYVVPDG ETRKIKHLRV FFVTAAWSIF AYTWLYIILS VSSPGVVEVW EGLLTFFFFP 240
ICVVFAWVAD RRLLFYKYVY KRYRAGKQRG MIIEHEGDRP ASKTEIEMDG KVVNSHVDNF 300
LDGALVLEVD ERDQDDEEAR REMARILKEL KQKHPDKEIE QLIELANYQV LSQQQKSRAF 360
YRIQATRLMT GAGNILKRHA ADQARKAVSM HEVNMDVVEN DPVSKVFFEQ GTYQCLENCG 420
TVALTIIRRG GDLTNTVFVD FRTEDGTANA GSDYEFTEGT VIFKPGETQK EIRVGIIDDD 480
IFEEDENFLV HLSNVRVSSE VSEDGILDSN HVSAIACLGS PNTATITIFD DDHAGIFTFE 540
EPVTHVSESI GIMEVKVLRT SGARGNVIIP YKTIEGTARG GGEDFEDTCG ELEFQNDEIV 600
KTISVKVIDD EEYEKNKTFF IEIGEPRLVE MSEKKGGFTL TEEYDDKQPL TSKEEEERRI 660
AEMGRPILGE HTKLEVIIEE SYEFKSTVDK LIKKTNLALV VGTNSWREQF IEAITVSAGE 720
DDDDDECGEE KLPSCFDYVM HFLTVFWKVL FAFVPPTEYW NGWACFIVSI LMIGLLTAFI 780
GDLASHFGCT IGLKDSVTAV VFVALGTSVP DTFASKVAAT QDQYADASIG NVTGSNAVNV 840
FLGIGVAWSI AAIYHAANGE QFKVSPGTLA FSVTLFTIFA FINVGVLLYR RRPEIGGELG 900
GPRTAKLLTS SLFVLLWLLY IFFSSLEAYC HIKGF 935 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0043198; C:dendritic shaft; IDA:RGD.
 GO:0043197; C:dendritic spine; IDA:RGD.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0014704; C:intercalated disc; IDA:BHF-UCL.
 GO:0005874; C:microtubule; IDA:RGD.
 GO:0005739; C:mitochondrion; IDA:RGD.
 GO:0030315; C:T-tubule; IDA:BHF-UCL.
 GO:0030018; C:Z disc; IDA:BHF-UCL.
 GO:0005432; F:calcium:sodium antiporter activity; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:1901660; P:calcium ion export; IDA:BHF-UCL.
 GO:0070509; P:calcium ion import; IDA:BHF-UCL.
 GO:0060402; P:calcium ion transport into cytosol; IDA:RGD.
 GO:0055013; P:cardiac muscle cell development; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IEA:Compara.
 GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; IDA:BHF-UCL.
 GO:0071320; P:cellular response to cAMP; IDA:RGD.
 GO:0034614; P:cellular response to reactive oxygen species; IDA:BHF-UCL.
 GO:0035050; P:embryonic heart tube development; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0048747; P:muscle fiber development; IEA:Compara.
 GO:0010763; P:positive regulation of fibroblast migration; IMP:RGD.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IDA:BHF-UCL.
 GO:0002028; P:regulation of sodium ion transport; IMP:RGD.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0033198; P:response to ATP; IDA:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0001666; P:response to hypoxia; IDA:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0071436; P:sodium ion export; IDA:BHF-UCL.
 GO:0097369; P:sodium ion import; IDA:BHF-UCL.
 GO:0021537; P:telencephalon development; IEP:RGD. 
Interpro
 IPR003644; Calx_beta.
 IPR001623; DnaJ_domain.
 IPR004836; Na_Ca_Ex.
 IPR002987; NaCa_exhngr1.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
  
PRINTS
 PR01259; NACAEXCHNGR.
 PR01260; NACAEXCHNGR1.